Results 61 to 70 of about 466,472 (359)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Fault tree analysis: A survey of the state-of-the-art in modeling, analysis and tools [PDF]

Computer Science Review, 2015
Fault tree analysis (FTA) is a very prominent method to analyze the risks related to safety and economically critical assets, like power plants, airplanes, data centers and web shops. FTA methods comprise of a wide variety of modelling and analysis techniques, supported by a wide range of software tools. This paper surveys over 150 papers on fault tree
Mariëlle Stoelinga, Enno Jozef Johannes Ruijters   +1 more
openaire   +2 more sources

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco, Mònica Roldán, Yalda Jamshidi, Ioannis Georvasilis, Rocío Jadraque Rodríguez, Reza Boostani, Ali Shoeibi, Lluís Armengol, Anna Codina, Ehsan Ghayoor Karimiani, Cristina Hernando‐Davalillo, Loreto Martorell, María Luisa Ramírez Almaraz, Jordi Muchart, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Daniel Natera‐de Benito, Mercedes Serrano   +18 more
wiley   +1 more source

Fault Tree Analysis for Robust Design

Designs
The objective of this research is to incorporate system failure into a robust design formation and solution process. The system failure referred to here will be built using fault tree analysis (FTA), which will take all lower-level failure events into ...
Jonathan DeGroff, Gene Jean-Win Hou
doaj   +1 more source

Fault Diagnosis Scheme Based on Microbial Fuel Cell Model

IEEE Access, 2020
Around the world, fossil fuels are decreasing and pollution is increasing. As a new energy source, microbial fuel cells (MFCs) have been widely concerned.
Fengying Ma, Lei Lian, Peng Ji, Yankai Yin, Wei Chen   +4 more
doaj   +1 more source

Cost‐effectiveness of low dose colchicine prophylaxis when starting allopurinol using the “start‐low go‐slow” approach for gout: evidence from a non‐inferiority randomised double‐blind placebo‐controlled trial.

Arthritis Care &Research, Accepted Article.
Objective The aim of this study was to investigate the cost‐effectiveness of low‐dose colchicine prophylaxis for preventing gout flares when starting allopurinol using the “start‐low go‐slow” approach. Methods Participants with gout, fulfilling the American College of Rheumatology recommendations for starting urate‐lowering therapy and with serum urate
Yana Pryymachenko, Ross Wilson, Nicola Dalbeth, J. Haxby Abbott, Lisa Stamp   +4 more
wiley   +1 more source

Exploring patients’ profiles associated with the resolution of acute calcium pyrophosphate arthritis treatedwith colchicine and prednisone: post hoc analysis of a randomized controlled trial

Arthritis Care &Research, Accepted Article.
Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart, Laurène Norberciak, Pascal Richette, Pierre Robinet, Aurore Pacaud, Gauthier Marchasson, Thibault Rabin, Hélène Luraschi, Pierre Maciejasz, Anne‐France Georgel, Augustin Latourte, Hang‐Korng Ea, Sébastien Ottaviani, Charlotte Jauffret, Vincent Ducoulombier   +14 more
wiley   +1 more source

Risk source identification and failure model for the operation of top tensioned riser

You-qi chuyun, 2020
The Top Tensioned Riser (TTR) is mainly applied to single column platforms and tension leg platforms in the development of deep water oil and gas. The risks in the operation of the TTR were analyzed to guarantee the safety and reliability of ocean ...
Jianxing YU, Tian LIU, Yang YU
doaj   +1 more source

THE FAULT TREE ANALYSIS OF AIRCRAFT HYDRAULIC BRAKE SYSTEM BASED ON HYPER-ELLIPSOIDAL MODEL

Jixie qiangdu, 2017
In fault tree analysis of aircraft hydraulic brake system,the probability statistical information of failure rate for bottom event is usually not sufficient.To solve this problem,a fault tree analysis method based on hyper-ellipsoidal model was given ...
ZHANG LeiLei, HE YiXiong, ZHAI WeiHao, ZHAO JunYao, ZHANG Feng   +4 more
doaj