Results 101 to 110 of about 612,817 (305)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

«The Great» dyke of the Bug area

Геофизический журнал, 2019
New data of geophysical, geochemical and petrologic studies of the well-known elongated 35km long linear geological structure of predictable fault-dyke nature in crystalline basement of the west part of the Bug mining area (Middle Bug area, the Ukrainian
V. A. Entin, O. B. Gintov, S. V. Mychak, V. N. Belskyi, Yu. V. Geyko, E. B. Polyachenko, S. I. Guskov, A. V. Marchenko   +7 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Fault tectonics and earthquake hazards in the Peninsular Ranges, Southern California [PDF]

The author has identified the following significant results. ERTS and Skylab images reveal a number of prominent lineaments in the basement terrane of the Peninsular Ranges, Southern California.
Lamar, D. L., Merifield, P. M.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Analysis of CO₂ leakage through "low-permeability" faults from natural reservoirs in the Colorado Plateau, southern Utah [PDF]

, 2004
The numerous CO2 reservoirs in the Colorado Plateau region of the United States are natural analogues for potential geologic CO2 sequestration repositories.
Evans, J.P., Heath, J., Kirchner, D., Kolesar, P.T., Shipton, Z.K., Williams, A.P.   +5 more
core  

Modeling and Recognition of Smart Grid Faults by a Combined Approach of Dissimilarity Learning and One-Class Classification

, 2014
Detecting faults in electrical power grids is of paramount importance, either from the electricity operator and consumer viewpoints. Modern electric power grids (smart grids) are equipped with smart sensors that allow to gather real-time information ...
De Santis, Enrico, Livi, Lorenzo, Rizzi, Antonello, Sadeghian, Alireza   +3 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A Review of Artificial Intelligence Applications in Predicting Faults in Electrical Machines

Energies
The operational efficiency of many industrial processes is greatly affected by condition monitoring, which has become more and more important in the detection and forecast of electrical machine failures.
Mathew Habyarimana, Abayomi A. Adebiyi
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source