Results 171 to 180 of about 882,077 (297)

Author Correction: Healthy forests safeguard traditional wild meat food systems in Amazonia. [PDF]

Nature
Antunes AP, de Araujo Lima Constantino P, Fa JE, Munari DP, Morcatty TQ, Jacob MCM, Nelson BW, Cassino MF, Carvalho EAR, Ickowitz A, Coad L, Bodmer RE, Mayor P, Richard-Hansen C, Valsecchi J, Campos-Silva JV, Pezzuti JCB, Aparício M, von Muhlen EM, Oliveira MA, de Paula MJ, Pimenta NC, de Mattos Vieira MAR, Santos Junior MA, Nunes AV, Boubli JP, Suruí LMG, Paumari ECS, Paumari AVC, Paumari JLVS, Paumari GC, Katukina APLR, Baniwa D, Baniwa VSM, Baniwa WSL, Baniwa AOF, Baniwa AB, Baniwa IJS, Waura Y, Silvestre Apurinã J, Apurinã VSS, Tikuna JOG, Tikuna EPAL, Kaxinauá JL, Kuikuro KB, Penaforth Kaixana JT, Rebelo GH, Torquato D, Apurinã VSF, Antúnez M, Perez-Peña PE, Fang TG, Puertas PE, Aquino RM, Maranhão L, Longin G, Lopes CKM, El Bizri HR.   +57 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Paleogenomic evidence on the temporal continuity of indigenous goat exploitation in the Canary Islands. [PDF]

iScience
Díaz-Pérez C, Santana J, Daly KG, Ordóñez AC, Serrano JG, Armas-Quintana SB, Vacas-Fumero E, Brito-Mayor A, Gilson SP, Morales J, Marrero Salas E, Hernández JC, Alberto V, Moreno M, Günther T, Morell Miranda P, Valdiosera C, Hernández M, Arnay M, Fregel R.   +19 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Well-Known, Misidentified, or Unnamed? A DNA Barcode-Based Reassessment of the Lepidoptera Fauna of Cyprus Supported by Morphology. [PDF]

Insects
Huemer P, Özden Ö, Rennwald E, Barton I, Junnilainen J, Hausmann A, van Nieukerken EJ, Hebert PDN.   +7 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Central Asian radiation of modern large-mammal faunas in Miocene. [PDF]

Sci Adv
Wang SQ, Jiangzuo Q, Bibi F, Zhang C, Li C, Li S, Fu J, Xing L, Jiang H, Guo D, Zhang Y, Ni X, Meng J, Deng T.   +13 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Mass extinction triggered the early radiations of jawed vertebrates and their jawless relatives (gnathostomes). [PDF]

Sci Adv
Hagiwara W, Sallan L.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source