Results 91 to 100 of about 16,624 (211)

Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus [PDF]

, 2017
Background In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimising personalised treatment strategies.
Carroll, M, Connor, J, Cossins, A, Duraffour, S, Fang, Y, Garcia-Dorival, I, Günther, S, Haldenby, S, Hall, Y, Hiscox, J, Kenny, J, Kerber, R, Krumkamp, R, Laws, T, Liu, X, Lüdtke, A, Matthews, D, Muñoz-Fontela, C, N’Faly, M, Rickett, N, Rockliffe, N, Sissoko, D, Speranza, E, Sprecher, A, Williamson, D, Xia, D, Zekeng, E   +26 more
core   +1 more source

Phase I Pharmacokinetics Study of Drug Areplivir® Zinc (INN: Favipiravir + Zinc Gluconate) (LLC "PROMOMED RUS", Russia)

Разработка и регистрация лекарственных средств
Introduction. Favipiravir is an antiviral compound that inhibits the RNA-dependent polymerase and possesses antiviral properties against RNA viruses, including SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2).
T. N. Komarov, N. S. Bagaeva, K. K. Karnakova, O. A. Archakova, D. S. Shchelgacheva, V. S. Shcherbakova, K. Ya. Zaslavskaya, P. A. Bely, A. V. Taganov, I. E. Shohin   +9 more
doaj   +1 more source

Efficacy of Convalescent Plasma in Relation to Dose of Ebola Virus Antibodies [PDF]

, 2016
International ...
Baize, S, Edwards, T, van Griensven, J
core   +3 more sources

Detection of Viral RNA in Tissues following Plasma Clearance from an Ebola Virus Infected Patient [PDF]

, 2016
An unprecedented Ebola virus (EBOV) epidemic occurred in 2013–2016 in West Africa. Over this time the epidemic exponentially grew and moved to Europe and North America, with several imported cases and many Health Care Workers (HCW) infected.
Biava, M, Bordi, L, Caglioti, C, Capobianchi, MR, Castilletti, C, Colavita, F, Di Caro, A, Hoenen, T, Ippolito, G, Kobinger, G, Lalle, E, Lanini, S, Lauria, FN, Nicastri, E, Petrosillo, N, Quartu, S, Zumla, A   +16 more
core   +4 more sources

Efficacy and cytotoxicity of novel antiviral compounds against Rift Valley Fever Virus [PDF]

, 2016
Rift Valley Fever virus (RVFV) is a ss-RNA virus from the Bunyaviridae family found in Africa and the Arabian Peninsula. The virus is usually transmitted by mosquitoes and predominantly affects livestock; however, humans exposed to bodily fluids or ...
Jung, David
core  

Inhibiting influenza virus replication using novel and established antiviral compounds

, 2011
Circulating influenza viruses have the potential to cause pandemics, as seen in 2009 with the emergence of a novel H1N1 virus that rapidly disseminated worldwide.
Brookes, Daniel William, Brookes, Daniel William   +1 more
core   +1 more source

Discovery of novel favipiravir derivatives with improved pharmacokinetic properties as anti-SFTSV agents

European Journal of Medicinal Chemistry Reports
Favipiravir is a nucleobase analogue that exhibits antiviral activities against a variety of RNA viruses. Due to the lack of antivirals to combat SFTS, an emerging tickborne epidemic caused by a RNA virus belonging to the Phenuividae family within ...
Xiaomeng He, Fan Wu, Wei Li, Runze Zhang, Ruiyang Sun, Zhihong Hu, Wu Zhong, Manli Wang   +7 more
doaj   +1 more source

Charakterisierung der Rolle des endosomalen Recycling-Systems für den intrazellulären Transport des Marburg Virus Glykoproteins [PDF]

, 2019
Das Marburg Virus (MARV), das zur Familie der Filoviridae gezählt wird, ist ein Erreger schwerer Fieber mit Letalitätsraten von bis zu 90 %. Das Glykoprotein GP stellt das einzige Oberflächenprotein des MARV dar und daher ist sein korrekter Transport zu ...
Halwe, Sandro
core   +1 more source

Assessing favipiravir impact on SARS-CoV-2 transmission within households: Insights from a multi-center study (FaviPrev)

Journal of Virus Eradication
Background: While certain studies have demonstrated that antiviral treatment administered to index patients with influenza can mitigate the transmission within households, the efficacy of anti-SARS-CoV-2 agents in curtailing household transmission ...
Taweegrit Siripongboonsitti, Marisa Muadchimkaew, Kriangkrai Tawinprai, Ornisa Issaranon, Wichuda Meepholkij, Pureepat Arttawejkul, Apiradee Vararungzarit, Onwalee Dhissayakamol, Wilaiporn Preeyachit, Kamonwan Soonklang, Nithi Mahanonda   +10 more
doaj   +1 more source

Two-dimensional IR spectroscopy of the anti-HIV agent KP1212 reveals protonated and neutral tautomers that influence pH-dependent mutagenicity [PDF]

, 2014
Antiviral drugs designed to accelerate viral mutation rates can drive a viral population to extinction in a process called lethal mutagenesis. One such molecule is 5,6-dihydro-5-aza-2′-deoxycytidine (KP1212), a selective mutagen that induces A-to-G and G-
Amariuta, Tiffany, Essigmann, John M., Fedeles, Bogdan I., Li, Deyu, Peng, Chunte, Singh, Vipender, Tokmakoff, Andrei   +6 more
core   +1 more source