Results 81 to 90 of about 16,624 (211)

Bee products as alternatives in the treatment of viral infections

Journal of the Science of Food and Agriculture, Volume 106, Issue 1, Page 33-54, 15 January 2026.
Abstract Medicines used in the treatment of viral infections usually reduce symptoms. There is a need to develop drugs that inhibit the viruses and do not merely relieve the symptoms. Natural bee products possess many pharmacological properties and are widely used in folk medicine. There are many studies on the antibacterial effects of bee products but
Michał Otręba, Łukasz Marek, Jerzy Stojko, Anna Rzepecka‐Stojko   +3 more
wiley   +1 more source

Characterization of susceptibility variants of poliovirus grown in the presence of favipiravir

Journal of Microbiology, Immunology and Infection, 2018
Background: T-705 (favipiravir) is a potent inhibitor of RNA-dependent RNA polymerases of influenza viruses and no favipiravir-resistant virus has been isolated.
Tohru Daikoku, Mineyuki Mizuguchi, Takayuki Obita, Takeshi Yokoyama, Yoshihiro Yoshida, Masaya Takemoto, Kimiyasu Shiraki   +6 more
doaj   +1 more source

Alphavirus polymerase and RNA replication [PDF]

, 2017
Alphaviruses are typically arthropod-borne, and many are important pathogens such as chikungunya virus. Alphaviruses encode four nonstructural proteins (nsP1-4), initially produced as a polyprotein P1234. nsP4 is the core RNA-dependent RNA polymerase but
Ahola, Tero, Hellström, Kirsi, Pietilä, Maija   +2 more
core   +1 more source

Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Based on N,N′‐Diphenylurea

ChemMedChem, Volume 21, Issue 1, January 2026.
Inhibitors of SARS‐CoV‐2 RdRp activity based on N,N′‐diphenylurea scaffold have been identified. Several compounds exhibit residual activity (RA) below 50% in an enzymatic assay (at 10 µM concentration) and improved aqueous solubility compared to the previously reported series of inhibitors.
Artem Chayka, Matěj Danda, Alžběta Dostálková, Vojtěch Spiwok, Lamija Zijadic, Anna Klimešová, Marina Kapisheva, Michala Zgarbová, Jan Weber, Tomáš Ruml, Michaela Rumlová, Zlatko Janeba   +11 more
wiley   +1 more source

Favipiravir. [PDF]

The Journal of the Association of Physicians of India, 2020
Agam, Vora, Mangesh, Tiwaskar
openaire   +3 more sources

Comparison of Routes of Administration, Frequency, and Duration of Favipiravir Treatment in Mouse and Guinea Pig Models of Ebola Virus Disease

Viruses
Favipiravir is a ribonucleoside analogue that has been explored as a therapeutic for the treatment of Ebola Virus Disease (EVD). Promising data from rodent models has informed nonhuman primate trials, as well as evaluation in patients during the 2013 ...
Dylan M. Johnson, Terry Juelich, Lihong Zhang, Jennifer K. Smith, Birte K. Kalveram, David Perez, Jeanon Smith, Michael R. Grimes, Tania Garron, Maricela Torres, Shane Massey, Trevor Brasel, David W. C. Beasley, Alex N. Freiberg, Jason E. Comer   +14 more
doaj   +1 more source

Fluorination methods in drug discovery [PDF]

, 2016
Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence that the fluorine atom can impart ...
Bonesi, Sergio Mauricio, Postigo, Jose Alberto, Yerien, Damián Emilio   +2 more
core   +1 more source

Assessing the Impact of Colchicine on Pulmonary Fibrosis Using Imaging in Patients With Moderate‐to‐Severe COVID‐19 Pneumonia

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Objective Pulmonary fibrosis may develop in patients with severe clinical conditions, especially those with high inflammatory indicators. We aimed to investigate the 15‐month follow‐up clinical outcomes in patients with moderate‐to‐severe COVID‐19 pneumonia treated with colchicine and to evaluate its potential in preventing post‐COVID pulmonary ...
Gulhan Ayhan Albayrak, Mustafa Ilteris Bardakci, Ugur Temel, Karuna Sharma   +3 more
wiley   +1 more source

Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen [PDF]

, 2017
Re-emergence of chikungunya virus, a mosquito-transmitted pathogen, is of serious public health concern. In the past 15 years, after decades of infrequent, sporadic outbreaks, the virus has caused major epidemic outbreaks in Africa, Asia, the Indian ...
Burt, Felicity J, Chen, Weiqiang, Herrero, Lara J, Kohl, Alain, Lenschow, Deborah J, Mahalingam, Suresh, Merits, Andres, Miner, Jonathan J, Ng, Lisa FP, Rudd, Penny A, Schnettler, Esther, Taylor, Adam, Zaid, Ali   +12 more
core   +1 more source

Safety and efficacy of favipiravir in COVID-19 patients with pneumonia. A randomized, double-blind, placebo-controlled study (FAVID)

Pneumonia
Purpose To design a randomized clinical trial to assess the efficacy and safety of favipiravir in patients with COVID-19 disease with pneumonia. Methods A randomized, double blind, placebo-controlled clinical trial of favipiravir in patients with COVID ...
Juan P. Horcajada, Rebeca Aldonza, Mónica Real, Silvia Castañeda-Espinosa, Elena Sendra, Joan Gomez-Junyent, Inmaculada López-Montesinos, Silvia Gómez-Zorrilla, Silvia Briansó, Montserrat Duran-Taberna, Andrés Fernández, Cristina Tarragó, Teresa Auguet-Quintillá, the COVID-MAR Research group, the COVID-HJ23 group   +14 more
doaj   +1 more source