Results 51 to 60 of about 16,624 (211)

Optimal Dose and Safety of Intravenous Favipiravir in Hospitalized Patients With COVID‐19: A Dose‐Escalating, Randomized Controlled Phase Ib Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1650-1661, June 2026.
AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland, Richard FitzGerald, Elizabeth Challenger, Laura Dickinson, Laura J. Else, Lauren Walker, Colin Hale, Victoria Shaw, Callum Kelly, Rebecca Lyon, Jennifer Gibney, Karim Dhamani, Margaret Irwin, Yvanne Enever, Michelle Tetlow, William Wood, Helen Reynolds, Justin Chiong, Orod Osanlou, Henry Pertinez, Katie Bullock, William Greenhalf, Andrew Owen, David G. Lalloo, Michael Jacobs, Julian A. Hiscox, Thomas Jaki, Pavel Mozgunov, Geoffrey Saunders, Gareth Griffiths, Saye H. Khoo, Thomas E. Fletcher, on behalf of the AGILE CST‐6 Study Group, Shazaad Ahmad, Christopher J. Edwards, Lesley Dry, Georgie McKenzie, Aleksandra Ros, Michael Stackpoole, Laura Bradley, Karen Jennings‐Wilding, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Steven Julious   +48 more
wiley   +1 more source

The cap-snatching SFTSV endonuclease domain is an antiviral target [PDF]

, 2020
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%-30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States.
Amarasinghe, Gaya K, Bowman, Gregory R, Choi, Younho, Frederick, Thomas E, Gross, Michael L, Jung, Jae U, Leung, Daisy W, Shin, Woo-Jin, Wang, Wenjie, Yoo, Ji-Seung, Zhang, Bojie, Zimmerman, Maxwell I   +11 more
core   +1 more source

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source

Ebola : too far or so close? [PDF]

, 2014
The year 2014 has witnessed the escalation of the largest ever Ebola outbreak which started in Guinea, and later spread to other countries in West Africa.
Pace, David, Torpiano, Paul
core  

Different SARS‐CoV‐2 Subvariants and Coagulation Markers Trend: A Retrospective Multicentric Study From Iranian Network for Research in Viral Diseases (INRVD)

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims This study aims to examine the prevalence and progression of coagulation disorders in adult COVID‐19 patients and evaluate the effect of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) on coagulation markers. Methods This retrospective study included 1885 hospitalized COVID‐19 patients, aged 20 to over 90 years,
Alireza Razavi, Masoud Pourghahramani Koltapeh, Tina Nazari, Arefe Morvaridi, Behrooz Banivaheb, Sepideh Saeb, Melina Moulaeian, Alireza Zakaryaei, Arash Sabzalian, Maedeh Raei, Bahar Razavi, Saeed Motlaghzadeh, Somayeh Sadat Hosseini, Hassan Karami, Parsa Ghafari, Amir Aboofazeli, Sogol Nastarvand, Negin Kaseb navaz Sarabi, Alex Avakian, Sara Ebadinejad, Tara Keyhani, Parand Danafar, Rozhin Rahimlou, Sedigheh Heidarian, Mozhgan Mondeali, Fatemeh Nafe‐Monfared, Mobina Jafarpour, Marziyeh Samiee, Fatemeh Birang, Amirhossein Mirzazadeh, Seyed Ariana Feiz Abadi, Khabat Barkhordari, Saba Siavoshi, Mahdi Biklari, Mohammad khodabakhsh, AmirHossein Javadi, Samaneh Mirzaee, Farshideh Didgar, Mostafa Etebari, Saedeh Soltanmohamad, Babak Shahbaz, Ebrahim Kord, Seyed Mohammad Hashemi Shahri, Majid Ebrahimzade, Alireza Ansari Moghaddam, Fariba Shahraki Sanavi, Afagh Moattari, Fahime Edalat, Majid Fardi Sheijani, Mohsen Moghadami, Tofigh Yaghubi, Ali Mojtahedi, Abtin Heidarzadeh, Mohammadreza Naghipour, Maryam Sharifi Luyeh, Pershang Nazemi, Kian Alipasandi, Maryam Albaji, Mahdieh Afzali, Nasim Shokouhi, Akram Ezani, Hamid reza Najari, Mirshamsedin Hosseini, Arefeh Ghobadi, Abdoalmabood Momeni, Seyedeh Zeinab Fattahi, Mehdi Mohsenzadeh, Mohammad Jafari, Adeleh Azizi, Sajad Pouryousef, Alijan Tabarraei, Abdolvahab Moradi, Sadeghali Azimi, Yousef Yahyapour, Masoumeh Bayani, Vahdat Poortahmasebi, Mojtaba Varshochi, Masood Ziaee, Shokouh Ghafari, Davod Javanmard, Alireza Soleimani, Sayed‐Hamidreza Mozhgani, Zakiye Mokhames, Zohreh Akhoundimeybodi, Akram Astani, Alireza Abdollahi, Azar Hadadi, Mohammad reza Salehi, Mahboubeh Hajiabdolbaghi, Seyed Reza Raeeskarami, Samira kafan, Mahnaz Montazeri, Marzieh Pazoki, Taghi Riahi, Mahshid Talebi‐Taher, Angila Ataei‐Pirkooh, Farah Bokharaei‐Salim, Seyed Hamid Reza Faiz, Saeed Kalantari, Zeinab Yasin, Seyed Mohammad Jazayeri   +100 more
wiley   +1 more source

Favipiravir Inhibits Mayaro Virus Infection in Mice

Viruses, 2021
Mayaro virus (MAYV) is an emergent alphavirus that causes MAYV fever. It is often associated with debilitating symptoms, particularly arthralgia and myalgia.
Michèle Bengue, Ai-rada Pintong, Florian Liegeois, Antoine Nougairède, Rodolphe Hamel, Julien Pompon, Xavier de Lamballerie, Pierre Roques, Valérie Choumet, Dorothée Missé   +9 more
doaj   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source

Favipiravir‐induced bradycardia: A case report

Clinical Case Reports
Key Clinical Message The purpose of this case report is to reveal one of the cardiovascular side effects of favipiravir, sinus bradycardia. Abstract Favipiravir has emerged as a potential treatment for COVID‐19, with its antiviral properties showing ...
Alireza Kashefizadeh, Laya Ohadi, Farbod Amiri, Maryam Abdolmaleki, Vahid Eslami, Mehrdad Jafari Fesharaki   +5 more
doaj   +1 more source

New insights into electronic and adsorption energies of metallofullerenes C19M

Results in Materials, 2023
A comprehensive electronic investigation was carried out by G09W program to provide new insights into the adsorption energies of metallofullerenes C19M (M = Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu and Zn). In this regard, the DFT calculations were performed on
A.A. El-Barbary, I.F.M. AL-Dosari
doaj   +1 more source

Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry [PDF]

, 2015
Emerging viral diseases pose a threat to the global population as intervention strategies are mainly limited to basic containment due to the lack of efficacious and approved vaccines and antiviral drugs.
A De Milito, A De Milito, A Freiberg, A Gulland, A Marzi, A Sheraly, A Yoshimura, B Bishop, B Elander, B Salvador, D Gatherer, D Vigerust, E Fellenius, E Ooi, E Wright, F Luciani, F Perut, F Turone, G Gehring, H Feldmann, H Kibuuka, J Kouznetsova, J Lalezari, J Ledgerwood, J Long, J Nuckols, J Pallister, J Tuukkanen, K Chandran, K Gnirss, K Maitland, K Mizunashi, K Mupapa, K Müller, K Saliba, K Schornberg, L Oestereich, M Brecher, M Rutz, N Paton, N Temperton, N White, O Hart, O Moncorgé, P Jahrling, P Madrid, R Dean, R Gasparini, R Kanapathipillai, R Wool-Lewis, S Avnet, S Baize, S Chikte, S Ekins, S Mather, S Smither, T Burnouf, T Lind, T Nagata, T Shintani, V Sandrin, V Tricou, W Howard, X De Lamballerie, X Qiu, Y Li   +65 more
core   +4 more sources