Results 101 to 110 of about 37,370 (239)

Targeting the miR‐224‐5p/PTEN pathway: A previously under‐characterized strategy to attenuate mesangial cell injury and predict prognosis in diabetic nephropathy

Journal of Diabetes Investigation, EarlyView.
Serum miR‐224‐5p levels are progressively elevated in diabetic nephropathy (DN) and serve as an independent predictor of a decline in eGFR of ≥30% over 2 years. Mechanistically, miR‐224‐5p directly targets PTEN 3’‐UTR, suppressing PTEN and the activation of the AKT pathway in high‐glucose‐stimulated mesangial cells.
Yanxia Gao, Xiaohui Zhang, Peng Lu, Qiang Wang   +3 more
wiley   +1 more source

Real‐world risk factors and clinical implications of early estimated glomerular filtration rate decline after sodium‐glucose cotransporter‐2 inhibitor therapy

Journal of Diabetes Investigation, EarlyView.
Older age, atrial fibrillation, loop diuretic use, and higher eGFR variability predicted early eGFR dip. Continued SGLT2 inhibitor therapy preserved long‐term kidney function, although closer monitoring is warranted in patients receiving loop diuretics. ABSTRACT Aim To assess the prevalence, risk factors, estimated glomerular filtration rate trajectory,
Jangwook Lee, Dayoung Kang, Kyoung‐Ah Kim, Han Seok Choi, Soomin Jo, Joeun Kim, Jae Yoon Park, Seung Eun Lee   +7 more
wiley   +1 more source

Association between fasting glucose/high-density lipoprotein cholesterol ratio and cardiovascular disease risk in Chinese middle-aged and older adults: a longitudinal study

Frontiers in Cardiovascular Medicine
BackgroundThere is currently no information on the association between the fasting blood glucose/high-density lipoprotein cholesterol ratio (FBG/HDL-C) and cardiovascular disease (CVD) incidence.MethodsParticipants in our study, sourced from the China ...
Jintao Chen, Liying Yan, Jianhai Chen
doaj   +1 more source

Assessing the Diagnostic Performance of Triglyceride–Glucose–Based Indices for Early Detection of Metabolic Syndrome in Paediatric Down Syndrome

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Down syndrome (DS) youth have an increased risk of metabolic syndrome (MetS). This study assessed the diagnostic performance of the triglyceride–glucose index (TyG) and its derivatives—TyG‐BMI, TyG‐waist circumference (WC) and TyG‐waist‐to‐height ratio (WHtR) in detecting MetS compared with traditional markers.
Valeria Calcaterra, Lucia Labati, Alessandra Anna Gazzarri, Alice De Lorenzo, Ilaria Anna Maria Scavone, Gianvincenzo Zuccotti   +5 more
wiley   +1 more source

A Multimodal Machine Learning Model for Framingham Risk Score–Based Cardiovascular Risk Stratification in Patients With Obstructive Sleep Apnea

Journal of Sleep Research, EarlyView.
ABSTRACT Machine learning provides a powerful tool to capture complex, nonlinear patterns in biomedical data and enhance precision risk stratification. In this study, we applied a multilayer perceptron (MLP) framework to classify Framingham Risk Score–based cardiovascular risk categories in patients with obstructive sleep apnea (OSA).
Feng Zhao, Yin Li, Chenyang Li, Huajun Xu, Enhui Zhou, Weijun Huang, Huaming Zhu, Jian Guan, Hongliang Yi, Jianyin Zou, Nutan Chen   +10 more
wiley   +1 more source

Efficacy of Exercise‐Based Interventions for Metabolic Syndrome: An Umbrella Review With Meta‐Analyses

Obesity Reviews, EarlyView.
ABSTRACT Background Regular exercise is a first‐line nonpharmacological strategy for managing metabolic syndrome (MetS), but varied exercise modalities and outcomes across studies have led to inconsistent findings that limit clinical guidance. Objective To synthesize up‐to‐date evidence on the efficacy of exercise‐based interventions in improving MetS ...
Eric Tsz‐Chun Poon, Hong‐Yat Li, Po‐San Wong, Wesley Man‐Kuk Sum, Jonathan Peter Little, Angelo Sabag   +5 more
wiley   +1 more source

Impact of Resistance Training on Body Composition, Physical Fitness, and Cardiometabolic Health in Children and Adolescents With Overweight/Obesity: An Umbrella Review With Meta‐Analyses

Obesity Reviews, EarlyView.
ABSTRACT Background Resistance training (RT) is increasingly recognized as a promising exercise modality for enhancing health and fitness in children and adolescents. However, evidence remains inconsistent in those with overweight/obesity. This umbrella review synthesized evidence from systematic reviews to evaluate RT effects on body composition ...
Eric Tsz‐Chun Poon, Jason Chun‐Kit Iu, Barry A. Franklin, Stuart M. Phillips, David R. Lubans, Brad J. Schoenfeld, Jordan J. Smith, Sarah G. Kennedy, Po‐San Wong, Alexios Batrakoulis   +9 more
wiley   +1 more source

IDENTIFICATION OF DISTROTIONS OF FBG SPECTRUM USING FIXED FBG FILTERS

, 2011
G.C. Kahandawa, J. A. Epaarachchi, H. Wang   +2 more
openaire   +2 more sources

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Sclerophyllous structural and chemical traits of mite‐induced galls on Crinodendron patagua (Elaeocarpaceae) leaves

Plant Biology, EarlyView.
Eriophyid mites reprogram the structural and biochemical traits of sclerophyllous leaves in Crinodendron patagua, promoting the formation of nutrient‐rich and protective gall tissues. Abstract Sclerophyllous plants present a suite of traits, including small, leathery leaves with thick cuticles, dense trichomes and sclerified tissues, which are often ...
L. M. Guedes, L. Rodríguez‐Cerda, N. Aguilera, E. Grandón, F. R. Valeriano, J. F. de Lima, J. F. P. de Oliveira, B. G. Ferreira   +7 more
wiley   +1 more source