Results 111 to 120 of about 37,370 (239)

Distinct clinical clusters of paediatric patients with status epilepticus: Retrospective cohort study

open access: yesDevelopmental Medicine &Child Neurology, Volume 68, Issue 9, Page 1305-1315, September 2026.
Large Swiss cohort of paediatric status epilepticus demonstrates that treatment delay (> 60 min) directly contributes to morbidity. Machine‐learning analysis of routine clinical data identifies three distinct patient clusters: febrile status epilepticus, severe para‐infectious status epilepticus, and status epilepticus in children with known epilepsy ...
Richard J Burman   +6 more
wiley   +1 more source

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

open access: yesArthritis &Rheumatology, Volume 78, Issue 8, Page 1765-1775, August 2026.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun   +13 more
wiley   +1 more source

Prediction Model for Mild Cognitive Impairment in Older Chinese Patients With Cerebral Small Vessel Disease Based on XGBoost Algorithms and Shapley Additive Explanations

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
An interpretable XGBoost‐SHAP model predicted MoCA‐defined cognitive impairment in older patients with cerebral small vessel disease and identified reduced IGF‐1 as the leading predictor. The model showed strong validation performance and clinical utility, supporting early risk stratification.
Peng Gao   +8 more
wiley   +1 more source

Cordyceps militaris Ethanol Extract Alleviates Hyperglycemia in Type 2 Diabetic Mice in Association With Gut Microbiota Modification

open access: yeseFood, Volume 7, Issue 4, August 2026.
Cordyceps militaris ethanol extract (CME) shows potential for ameliorating glucose and lipid metabolism in T2DM mice. The improvements are correlated with the regulation of gut microbiota and increased short‐chain fatty acid levels, offering a novel perspective for future diabetes interventions.
Huanhuan Wen   +10 more
wiley   +1 more source

Moutan Cortex Extract Mediates Diabetic Retinopathy by Blocking the ROS‑Triggered HIF‐1α/VEGF Axis in Retinal Pigment Epithelial Cells

open access: yeseFood, Volume 7, Issue 4, August 2026.
Schematic diagram of the mechanism by which Moutan Cortex extract (MCE) ameliorates DR. MCE alleviates retinal structural damage and reduces neovascular lesions by downregulating the ROS/HIF‐1α/VEGF signaling axis. ABSTRACT Moutan Cortex is a functional food ingredient with multiple health benefits, but its effects on diabetic retinopathy (DR) remain ...
Mei‐rong Li   +13 more
wiley   +1 more source

3,3′,4,5′‐Tetramethoxy‐trans‐stilbene Alleviates Metabolic Dysfunction‐Associated Steatotic Liver Disease

open access: yeseFood, Volume 7, Issue 4, August 2026.
3,3′,4,5′‐Tetramethoxy‐trans‐stilbene alleviates hepatic insulin resistance and metabolic dysfunction‐associated steatotic liver disease, through the activation of IRS/PI3K/Akt/GSK3β/GS and Nrf2/HO‐1 pathways, in diet‐induced obese mice. The figure was created with MedPeer (medpeer.cn).
Qiaowen Deng   +6 more
wiley   +1 more source

Investigating the Antidiabetic Effects of Calotropis procera: Preclinical Assessment

open access: yesFood Science &Nutrition, Volume 14, Issue 8, August 2026.
Calotropis Procera In vitro/Diabetic rodent model Improved β‐cell function, reduced hepatic gluconeogenesis antioxidant activity. ABSTRACT Diabetes mellitus (DM) is a metabolic disease characterized by persistent hyperglycemia, oxidative stress, and inflammation, often leading to severe complications.
Yu‐Cheng Kuo   +10 more
wiley   +1 more source

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