Results 161 to 170 of about 60,037 (282)

Exploring the Therapeutic Potential of Metformin and Vitamin D3 Combination in the Management of Diabetes Mellitus

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Metformin and vitamin D3, particularly in combination, improved glycaemic control, lipid profile, liver function, and pancreatic histoarchitecture in STZ‐induced diabetic mice. These findings suggest potential for combination therapy as a complementary approach to diabetes management.
Md. Ferdaus Azam   +9 more
wiley   +1 more source

A Selenium‐Enriched Composite From Edible Mushrooms and Medicinal Plants Ameliorates Metabolic Disorders via Multi‐Target Network Modulation

open access: yesFood Science &Nutrition, Volume 14, Issue 11, November 2026.
Inspired by the dietary habits of centenarians in Enshi, China, two selenium‐enriched water‐soluble powder formulations (OFXBJC and NFXBJC) were developed from edible mushrooms and medicinal plants. NFXBJC exhibited higher bioactive components and hypoglycemic metabolites, and was selected for subsequent evaluations.
Wuxian Zhou   +9 more
wiley   +1 more source

Association of SDF‐1β (rs1801157) and TCF7L2 (rs12255372) Gene Polymorphisms With Type 2 Diabetes Mellitus in the Bangladeshi Population: A Case‐Control Study

open access: yesHealth Science Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Aims Type 2 diabetes mellitus (T2DM) has a strong genetic component and variations in specific gene alleles can significantly influence individual susceptibility. Stromal cell‐derived factor‐1 beta (SDF‐1β) plays a crucial role in inflammatory responses, glucose regulation, and the maintenance of pancreatic β‐cell function, while TCF7L2, a key
Md. Abdullah Al Mobin   +11 more
wiley   +1 more source

Association Between Sugar‐Sweetened Beverage Consumption and All‐Cause Mortality in Individuals With and Without Metabolic Syndrome: A Prospective Cohort Study

open access: yesHealth Science Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background and Aims To examine the association between sugar‐sweetened beverage (SSB) intake and all‐cause mortality among U.S. adults with and without metabolic syndrome (MetS), and to identify potential nonlinear dose‐response relationships and high‐risk subpopulations. Methods We analyzed data from 26,885 U.S.
Tingting Lv   +3 more
wiley   +1 more source

Association of Vascular Endothelial Growth Factor A +936 C/T Polymorphism With Non‐Alcoholic Fatty Liver Disease in a Bangladeshi Population: A Case‐Control Study

open access: yesHealth Science Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background and Aims Non‐Alcoholic Fatty Liver Disease (NAFLD) ranges from hepatic steatosis to advanced cirrhosis. Polymorphisms in the vascular endothelial growth factor A (VEGFA) gene can change its expression, potentially altering angiogenesis and advancing disease stage. This study aimed to evaluate the association between the VEGFA +936 C/
Rakibul Hasan Shanto   +9 more
wiley   +1 more source

BDH1 Attenuates Macrophage Foam Cell Formation and Inflammation in Atherosclerosis Via Modulating Histone H3K9 Acylation Balance and Activating PPAR Signaling

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
In atherosclerotic lesions, BDH1 expression is downregulated in plaque macrophages. In ox‐LDL‐induced RAW264.7 macrophages, BDH1 overexpression maintains H3K9 acylation homeostasis by upregulating H3K9ac and downregulating H3K9bhb, thereby increasing cell viability, reducing lipid accumulation, decreasing TNF‐α, and increasing IL‐10.
Yu Wang   +6 more
wiley   +1 more source

PEGylated Chrysin: In Vitro Biological Activity and Mechanistic Insights in HepG2 Cells

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
PEGylated chrysin exhibited antiproliferative effects in HepG2 cells, inducing apoptosis, membrane damage, genotoxicity, and wound closure. Compared to paclitaxel, it caused lower ROS production and overall cytotoxicity, while efficiently accumulating in the cytoplasm, supporting its potential as a liver cancer therapeutic candidate. ABSTRACT PEGylated
Fátima Belén Gasser   +9 more
wiley   +1 more source

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