Results 101 to 110 of about 4,235 (189)

Understanding the Variability of Peanut‐Oral Immunotherapy Responses by Multi‐Omics Profiling of Immune Cells

Allergy, Volume 80, Issue 12, Page 3342-3358, December 2025.
This study analyzes molecular drivers of OIT responsiveness. Multi‐omics profiling of peanut‐stimulated PBMCs in a controlled peanut‐OIT trial identifies immune, transcriptomic, and epigenetic changes distinguishing complete responders from incomplete responders. Key findings highlight gastrointestinal immune mechanisms, including extracellular exosome
Aleix Arnau‐Soler, Sarah E. Ashley, Ahla Ghauri, Alexander C. S. N. Jeanrenaud, Ingo Marenholz, Katharina Blumchen, Penelope Cibin, Alisa Iakupova, Norbert Hubner, Kirsten Beyer, Young‐Ae Lee   +10 more
wiley   +1 more source

FIBRILLINS IN TENDON

Frontiers in Aging Neuroscience, 2016
Tendons among connective tissue, mainly collagen, contain also elastic fibres made of fibrillin 1, fibrillin 2 and elastin that are broadly distributed in tendons and represent 1-2% of the dried mass of the tendon.
Betti Giusti, Guglielmina Pepe
doaj   +1 more source

Multijet Discriminators for New Physics in Leptonic Signals at the LHC [PDF]

, 2009
Some of the cleanest signals for new physics in the early runs of the LHC will involve strongly-produced particles which give rise to multiple leptons by undergoing cascade decays through weakly-interacting states to stable particles.
A. Datta, Anirban Kundu, Biplob Bhattacherjee, Santosh Kumar Rai, Sreerup Raychaudhuri   +4 more
core   +1 more source

Centimeter‐Scale Self‐Assembling Tendon Organoids Drive Tissue Regeneration

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Centimeter‐scale tendon organoids are engineered by mimicking the extracellular matrix and optimizing chemical cues to guide tendon stem/progenitor cells. These large, self‐assembling constructs overcome conventional size limitations and exhibit enhanced tenogenic differentiation, extracellular matrix production, and mechanical resilience. Their tissue‐
Tianshun Fang, Hong Zhang, Yuanhao Xie, Xiongfeng Li, Xi Liu, Zichen Wang, Yiwen Xue, Xiaohui Xia, Zetao Wang, Tingyun Lei, Ruifu Lin, Weiliang Shen, Bingbing Wu, Yishan Chen, Yanan Du, Xiao Chen, Zi Yin   +16 more
wiley   +1 more source

De novo mutations in histone modifying genes in congenital heart disease [PDF]

, 2013
Congenital heart disease (CHD) is the most frequent birth defect, affecting 0.8% of live births1. Many cases occur sporadically and impair reproductive fitness, suggesting a role for de novo mutations.
Bjornson, Robert D., Breitbart, Roger E., Brown, Kerry K., Brueckner, Martina, Carriero, Nicholas J., Cheung, Yee Him, Choi, Murim, Chung, Wendy K., Deanfield, John, DePalma, Steve, Fakhro, Khalid A., Gelb, Bruce D., Glessner, Joseph, Goldmuntz, Elizabeth, Hakonarson, Hakon, Italia, Michael, Jiang, Jianming, Kaltman, Jonathan R., Kaski, Juan, Kim, Richard, Kline, Jennie K., Lee, Teresa, Leipzig, Jeremy, Lifton, Richard P., Lopez, Alexander, Ma, Lijiang, Mane, Shrikant M., Mitchell, Laura E., Newburger, Jane W., Overton, John D., Parfenov, Michael, Pe'er, Itsik, Porter, George, Roberts, Amy, Romano-Adesman, Angela, Sachidanandam, Ravi, Sanders, Stephan J., Seiden, Howard S., Seidman, Christine E., Seidman, Jonathan G., State, Mathew W., Subramanian, Sailakshmi, Tikhonova, Irina R., Wakimoto, Hiroko, Wang, Wei, Warburton, Dorothy, White, Peter S., Williams, Ismee A., Zaidi, Samir, Zhao, Hongyu   +49 more
core   +1 more source

Fibulin Family Members: New Players in Liver Fibrosis and Potential Biomarkers in Chronic Liver Diseases

Hepatology Research, Volume 55, Issue 11, Page 1425-1436, November 2025.
ABSTRACT Chronic liver diseases (CLD) arising from various etiologies including viral hepatitis, excessive alcohol intake, alcoholic associated liver disease (ALD) and metabolic dysfunction‐associated steatotic liver disease (MASLD), are associated with persistent hepatic injury ultimately resulting in fibrosis.
Fidaa Bouezzedine, Célia Thomas, Nathalie Théret   +2 more
wiley   +1 more source

Assessing the impact of storage conditions on RNA from human saliva and its application to the identification of mRNA biomarkers for asthma

Frontiers in Molecular Biosciences
Introduction: Human saliva was used to develop non-invasive liquid biopsy biomarkers to establish saliva as an alternate to blood and plasma in translational research.
Poorna Manasa Bhamidimarri, David Fuentes, Laila Salameh, Laila Salameh, Bassam Mahboub, Bassam Mahboub, Rifat Hamoudi, Rifat Hamoudi, Rifat Hamoudi, Rifat Hamoudi, Rifat Hamoudi   +10 more
doaj   +1 more source

A New Class of Multiple-rate Codes Based on Block Markov Superposition Transmission

, 2014
Hadamard transform~(HT) as over the binary field provides a natural way to implement multiple-rate codes~(referred to as {\em HT-coset codes}), where the code length $N=2^p$ is fixed but the code dimension $K$ can be varied from $1$ to $N-1$ by adjusting
Bai, Baoming, Hu, Jingnan, Liang, Chulong, Ma, Xiao   +3 more
core   +1 more source

Identification of a Novel Missense FBN2 Mutation in a Chinese Family with Congenital Contractural Arachnodactyly Using Exome Sequencing.

PLoS ONE, 2016
Congenital contractural arachnodactyly (CCA, OMIM 121050), also known as Beals-Hecht syndrome, is an autosomal dominant disorder of connective tissue.
Hao Deng, Qian Lu, Hongbo Xu, Xiong Deng, Lamei Yuan, Zhijian Yang, Yi Guo, Qiongfen Lin, Jingjing Xiao, Liping Guan, Zhi Song   +10 more
doaj   +1 more source

Marfan Syndrome, A Review

Journal of Biomedicine and Translational Research, 2018
Marfan syndrome is named after the French pediatrician Antoine Bernard-Jean Marfan who described in 1896 a girl with arachnodactyly and long limbs1. The patient also had congenital contractures of the elbows and would not fulfill the current criteria for
Gerard Pals
doaj   +1 more source