Results 81 to 90 of about 24,384 (198)
The yin and yang of Fcγ receptors in ITP [PDF]
, 2008 The Fcγ receptors contribute to the susceptibility to autoimmune diseases such as ITP in several ways: (1) they modulate dendritic cell antigen processing and presentation, (2) they modulate antibody production by B cells, and (3) they participate in ...
McKenzie, Steven E.
core +1 more source
Target shape dependence in a simple model of receptor-mediated endocytosis and phagocytosis [PDF]
, 2016 Phagocytosis and receptor-mediated endocytosis are vitally important particle uptake mechanisms in many cell types, ranging from single-cell organisms to immune cells.
Endres, Robert G., Richards, David M.
core +2 more sources
Mass Spectrometry Reviews, EarlyView.ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu +5 more
wiley +1 more source
Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells
Allergy, EarlyView.We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller +16 more
wiley +1 more source
The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models. [PDF]
, 2016 Toll-like receptors (TLRs) play an important role in the innate and adaptive immune responses to pathogens, and are the target of new vaccine adjuvants.
Bates, PA +4 more
core +7 more sources
Birth‐Related Experiences and Postpartum Depression: The Protective Role of Self‐Compassion
Birth, EarlyView.Does self‐compassion (SC) moderate the relationship between birth satisfaction, type of birth, and early skin‐to‐skin contact (SSC) in women's PPD symptoms? Methods: 987 women with an infant aged 0–5 months. 62.1% Vaginal delivery. 66.3% SSC contact after delivery.
Helena Moreira, Colin R. Martin
wiley +1 more source
Polymorphism of Human FcγRIIa and Its Association with P. Falciparum Density and Efficacy of Dihydroartemisinin- Piperaquine [PDF]
, 2016 FcγRlla dimorphism has been related to the ability of the host to eliminate malaria parasite so it is necessary to investigate the allele polymorphism FcγRlla of population in malaria-endemic areas in Indonesia in order to know the role of ...
Asih, P. B. (Puji) +6 more
core +2 more sources
British Journal of Haematology, EarlyView.Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu +8 more
wiley +1 more source
Child &Family Social Work, EarlyView.ABSTRACT Safeguarding Family Group Conferencing (FGC) is a family‐led decision‐making process offered to some families in England as an alternative to an Initial Child Protection Conference when Children's Services have safeguarding concerns. A realist evaluation was conducted within three local authorities piloting this approach to build understanding
Bekkah Bernheim +5 more
wiley +1 more source
The antibody loci of the domestic goat (Capra hircus) [PDF]
, 2018 The domestic goat (Capra hircus) is an important ruminant species both as a source of antibody-based reagents for research and biomedical applications and as an economically important animal for agriculture, particularly for developing nations that ...
Bickhart, Derek M. +4 more
core +1 more source