Results 121 to 130 of about 14,752 (202)

Nipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties

mAbs
Nipocalimab is a human immunoglobulin G (IgG)1 monoclonal antibody that binds to the neonatal Fc receptor (FcRn) with high specificity and high affinity at both neutral (extracellular) and acidic (intracellular) pH, resulting in the reduction of ...
Nilufer P. Seth, Rui Xu, Matthew DuPrie, Amit Choudhury, Samuel Sihapong, Steven Tyler, James Meador, William Avery, Edward Cochran, Thomas Daly, Julia Brown, Laura Rutitzky, Lynn Markowitz, Sujatha Kumar, Traymon Beavers, Sayak Bhattacharya, Hsin Chen, Viraj Parge, Karen Price, Yang Wang, Siddharth Sukumaran, Yvonne Pao, Katie Abouzahr, Fiona Elwood, Jay Duffner, Sucharita Roy, Pushpa Narayanaswami, Jonathan J. Hubbard, Leona E. Ling   +28 more
doaj   +1 more source

Inhibition of Maternal-to-Fetal Transfer of IgG Antibodies by FcRn Blockade in a Mouse Model of Arthrogryposis Multiplex Congenita [PDF]

, 2021
Estér Coutinho, Leslie Jacobson, Anthony Shock, Bryan Smith, Anthony C. Vernon, Angela Vincent   +5 more
openalex   +1 more source

Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn

mAbs
Monoclonal antibodies (mAbs) as therapeutics necessitate favorable pharmacokinetic properties, including extended serum half-life, achieved through pH-dependent binding to the neonatal Fc receptor (FcRn).
Johannes Reusch, Jan Terje Andersen, Ulrich Rant, Tilman Schlothauer   +3 more
doaj   +1 more source

FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines

npj Vaccines
Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies (mAb) to target antigen to specific DC subsets.
Christophe Macri, Matthew Paxman, Devi Jenika, Xiao Peng Lin, Zahra Elahi, Paul A. Gleeson, Irina Caminschi, Mireille H. Lahoud, Jose A. Villadangos, Justine D. Mintern   +9 more
doaj   +1 more source

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics [PDF]

, 2017
Nicole Piche‐Nicholas, Lindsay B. Avery, Amy King, Mania Kavosi, Mengmeng Wang, Denise M. O’Hara, Lioudmila Tchistiakova, Madan Katragadda   +7 more
openalex   +1 more source

TGEV infection up-regulates FcRn expression via activation of NF-κB signaling [PDF]

, 2016
Jinyue Guo, Fei Li, Shaoju Qian, Dingren Bi, Qigai He, Hui Jin, Rui Luo, Shaowen Li, Xianrong Meng, Zili Li   +9 more
openalex   +1 more source

Deep Residual Echo Suppression and Noise Reduction: A Multi-Input FCRN Approach in a Hybrid Speech Enhancement System [PDF]

, 2021
Jan Franzen, Tim Fingscheidt
openalex   +1 more source

FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques

mAbs
Prenatal administration of monoclonal antibodies (mAbs) is a strategy that could be exploited to prevent viral infections during pregnancy and early life.
Joanna Zikos, Gabriela M. Webb, Helen L. Wu, Jason S. Reed, Jennifer Watanabe, Jodie L. Usachenko, Ala M. Shaqra, Celia A. Schiffer, Koen K. A. Van Rompay, Jonah B. Sacha, Diogo M. Magnani   +10 more
doaj   +1 more source

Proof-of-concept and Randomized, Placebo-controlled Trials of an FcRn Inhibitor, Batoclimab, for Thyroid Eye Disease [PDF]

, 2023
George J. Kahaly, Peter J. Dolman, Jan Wolf, Bert C. Giers, Heike M. Elflein, Amy Patel Jain, Ashok Srinivasan, Lubomir M. Hadjiiski, David R. Jordan, Elizabeth A. Bradley, Marius N. Stan, Anja Eckstein, Susanne Pitz, Christian Vorländer, Sara T. Wester, John Nguyen, Nancy Tucker, Marco Sales‐Sanz, Steven E. Feldon, Christine C. Nelson, Isabelle Hardy, Maravillas Abia Serrano, Philip Tedeschi, Jonathan Janes, Jing Xu, Peter Vue, William L. Macias, Raymond S. Douglas   +27 more
openalex   +1 more source

Loss of expression of the recycling receptor, FcRn, promotes tumor cell growth by increasing albumin consumption

, 2016
Rafal Swiercz, Min Mo, Priyanka Khare, Zita Schneider, Raimund J. Ober, E. Sally Ward   +5 more
openalex   +2 more sources