Results 121 to 130 of about 8,114 (214)

Improving drug-like properties of protein therapeutics through peptide extensions that interact with the Fc fragment of IgG receptor transporter-α (FCGRT; FCRN) [PDF]

, 2012

openalex   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Mirvetuximab Soravtansine: Mechanism of Action, Clinical and Translational Science

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Mirvetuximab soravtansine (MIRV) is an antibody‐drug conjugate (ADC) composed of the DM4 payload conjugated to a folate receptor α (FRα)‐targeting antibody via the cleavable sulfo‐SPDB linker. MIRV targets and binds to FRα with high affinity and specificity, releasing the DM4 payload intracellularly following MIRV‐FRα complex internalization ...
Rajeev Menon, Emarjola Bako, Shuhan Liu, James Stec, Sheetal Thakur, Emily Deutschman, Olga Ab, Shweta Jain   +7 more
wiley   +1 more source

Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn) [PDF]

, 2006
William F. Dall’Acqua, Peter A. Kiener, Herren Wu   +2 more
openalex   +1 more source

Serum Autoantibody Lowering by the Anti-FcRn Monoclonal Antibody, Nipocalimab, Correlates With Clinical Improvement in Generalized Myasthenia Gravis Patients [PDF]

, 2022
Sindhu Ramchandren, Jeff Guptill, Carlo Antozzi, Vera Bril, Josep Gámez, Sven G. Meuth, Richard M. Nowak, Dianna Quan, Maria Teresa Sevilla Mantecon, Leona Ling, Yaowei Zhu, Keith Karcher, Hong Sun   +12 more
openalex   +1 more source

pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling [PDF]

, 2014
M. Jack Borrok, Yanli Wu, Nurten Beyaz, Xiang‐Qing Yu, Vaheh Oganesyan, William F. Dall’Acqua, Ping Tsui   +6 more
openalex   +1 more source

Structural Design and Immunogenicity of a Novel Self‐Adjuvanting Mucosal Vaccine Candidate for SARS‐CoV‐2 Expressed in Plants

Plant Biotechnology Journal, Volume 24, Issue 1, Page 284-299, January 2026.
ABSTRACT Mucosal vaccination for COVID‐19 to boost preexisting though insufficient systemic and local/mucosal immunity remains an attractive prospect but there are currently no licensed mucosal vaccines against this infection. Here, using a plant expression system, we developed a novel mucosal vaccine platform for respiratory viruses and demonstrated ...
Mi‐Young Kim, Andy Cano Tran, Ju Kim, Humblenoble Stembridge Ayuk, Adam Sparrow, Lorenzo Bossi, Megan Brown, Emil Joseph Vergara, Kathrin Göritzer, Elisabetta Groppelli, Tae‐Ho Kwon, Julian K. C. Ma, Yong‐Suk Jang, Rajko Reljic   +13 more
wiley   +1 more source

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics [PDF]

, 2017
Nicole Piche‐Nicholas, Lindsay B. Avery, Amy King, Mania Kavosi, Mengmeng Wang, Denise M. O’Hara, Lioudmila Tchistiakova, Madan Katragadda   +7 more
openalex   +1 more source

Identifying Red Flags in Myasthenia Gravis Diagnosis, Reassessment, and Myasthenic Crisis: An Italian Delphi‐Based Position Paper

Acta Neurologica Scandinavica, Volume 2026, Issue 1, 2026.
Background and Purpose Myasthenia gravis (MG) is a complex autoimmune disorder affecting neuromuscular transmission, often leading to diagnostic and therapeutic challenges. Timely identification of “red flags” in diagnosis, therapeutic reassessment, and myasthenic crisis is crucial to optimizing patient outcomes. This Delphi‐based consensus is aimed at
Francesco Habetswallner, Luca Bello, Fiammetta Biasini, Bernardo Maria De Martino, Fiammetta Vanoli, Paolo E. Alboini, Giovanni Antonini, Carlo Antozzi, Valentina Damato, Vincenzo Di Stefano, Amelia Evoli, Matteo Gastaldi, Raffaele Iorio, Michelangelo Maestri, Renato Mantegazza, Roberto Massa, Rita Rinaldi, Francesco Saccà, Carmelo Rodolico, Dominic B. Fee   +19 more
wiley   +1 more source

The neonatal Fc receptor (FcRn) is required for porcine reproductive and respiratory syndrome virus uncoating

Journal of Virology
Porcine reproductive and respiratory syndrome virus (PRRSV) continues to cause substantial economic losses to the pig industry worldwide. Previous studies from other groups showed that CD163 is required for PRRSV uncoating and genome release.
Kang Yang, Jiarui Dong, Jian Li, Rui Zhou, Xiangchao Jia, Zhijian Sun, Weida Zhang, Zili Li   +7 more
doaj   +1 more source