Results 121 to 130 of about 15,564 (249)

Effects of Prepartum Supplementation and Yeast Fermentation Products on the Progesterone‐Modulated Transfer of Passive Immunity in Bos indicus Cows

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Inadequate colostrum intake increases risks of calf morbidity and mortality. This study investigated the effects of prepartum and early postpartum supplementation and yeast fermentation products on late‐pregnant Bos indicus cows, and the role of progesterone in mediating passive immunity transfer.
Latino G. S. Coimbra, Fran C. Cowley, Geoffry Fordyce, Luis F. P. Silva   +3 more
wiley   +1 more source

Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation

Communications Biology
IgGs have become successful drug scaffolds by combining specific target binding with the ability to induce cellular cytotoxicity. Furthermore, IgGs possess unusually long half-lives in the blood (2-3 weeks).
Esben Trabjerg, Jeannette Nilsen, Torleif Tollefsrud Gjølberg, Jan Terje Andersen, Alexander Leitner, Kasper D. Rand   +5 more
doaj   +1 more source

A szarvasmarha neonatalis Fc receptor (bFcRn) által mediált IgG katabolizmus és epithelialis transzport molekuláris szintű elemzése = Studies on the bovine FcRn mediated IgG catabolism and epithelial transport at molecular level [PDF]

, 2009
A pályázat révén jelentősen bővítettük a szarvasmarha FcRn (bFcRn) szerepéről alkotott ismereteinket arról hogyan szabályozza ez a receptor az IgG homeosztázisát.
Doleschall, Márton, Frenyó, Vilmos László, Jancsik, Veronika, Kacskovics, Imre, Kis, Zsuzsanna, Mayer, Balázs   +5 more
core  

FcRn Expression on Placenta and Fetal Jejunum during Early, Mid-, and Late Gestation in Minipigs [PDF]

, 2015
Björn Jacobsen, Marilyn Hill, Lucie Reynaud, Adam Hey, Paul Barrow   +4 more
openalex   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Immunoglobulin G Levels in Yemeni Preterm Newborns: Infant Factors Predominate

Reproductive, Female and Child Health, Volume 5, Issue 2, June 2026.
ABSTRACT Background IgG levels in preterm infants play a crucial role in response to infection and inflammation. Infectious disease burden in the low‐income countries, such as Yemen, exacerbates the problem. The preterm infant's IgG sources are either maternal or fetal immune system.
Antar F. A. M. Al‐Badani, Jamil M. A. S. Obaid, Safana M. H. Al‐Sofi, Rahma A. S. Al‐Mansoub   +3 more
wiley   +1 more source

A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

CPT: Pharmacometrics & Systems Pharmacology, 2019
Monoclonal antibody (mAb) pharmacokinetics (PK) have largely been predicted via allometric scaling with little consideration for cross‐species differences in neonatal Fc receptor (FcRn) affinity or clearance/distribution mechanisms.
Hannah M. Jones, Zhiwei Zhang, Paul Jasper, Haobin Luo, Lindsay B. Avery, Lindsay E. King, Hendrik Neubert, Hugh A. Barton, Alison M. Betts, Robert Webster   +9 more
doaj   +1 more source

Repurpose an FDA‐Approved Antibody Using DARPin‐Scaffolded Bridge Protein

Chemistry–Methods, Volume 6, Issue 5, May 2026.
The cell line and scalable upstream/downstream process development needed for every new monoclonal antibody are both highly expensive and time‐consuming, significantly increasing the cost of new antibody therapeutics. By contrast, the production of many synthetic binders can be accomplished rapidly and with lower production costs.
Michael Woolley, Joshua D. Bryant, Samuel Vrana, Karuppiah Chockalingam, Zhilei Chen   +4 more
wiley   +1 more source

Factors associated with response to rituximab in patients with immune thrombocytopenia

HemaSphere, Volume 10, Issue 5, May 2026.
Abstract Rituximab is a well‐established treatment for adult immune thrombocytopenia (ITP), with ~60% initial response (IR) and 20%–30% long‐term remissions. We conducted a register‐based cohort study of 759 ITP patients in Sweden, Denmark, and Norway treated with rituximab (2009–2018) to identify factors associated with response.
Galina Tsykunova, Eskild Bendix Kristiansen, Tor Henrik Anderson Tvedt, Henrik Frederiksen, Christian Fynbo Christiansen, Marie Linder, Shahram Bahmanyar, Waleed Ghanima   +7 more
wiley   +1 more source

Human FcRn can mediate the transport across intestinal mucosal barrier and prolong the half-life of rabbit IgG in vivo [PDF]

, 2015
Guangchang Pang, Yufang Wang, Junbo Xie, Qingsen Chen, HU Zhi-he   +4 more
openalex   +1 more source