Results 31 to 40 of about 272,653 (310)

Torsadogenic risk of antipsychotics : combining adverse event reports with drug utilization data across Europe [PDF]

, 2013
Antipsychotics (APs) have been associated with risk of torsade de Pointes (TdP). This has important public health implications. Therefore, (a) we exploited the public FDA Adverse Event Reporting System (FAERS) to characterize their torsadogenic profile; (
Barbui, Corrado, Sturkenboom, Miriam, Barbui Corrado, Marija Kalaba (487415), Miriam Sturkenboom (408749), Barbui, C. (Corrado), Corrado Barbui, Kalaba M, Sturkenboom M, Fabrizio De Ponti (487418), Godman, Brian, Ariola Koci, Raschi, E. (Emanuel), Ponti, F. (Fabrizio) de, Poluzzi Elisabetta, Koci, A. (Ariola), Bjorn Wettermark, Elisabetta Poluzzi, Moretti, U. (Ugo), Miriam Sturkenboom, Godman Brian, Koci Ariola, Bennie, Marion, Brian Godman (487412), Godman B, Moretti U, Moretti Ugo, Koci, Ariola, De Ponti Fabrizio, Godman, B. (Brian), Sturkenboom Miriam, Wettermark B, Sturkenboom, M.C.J.M. (Miriam), Marija Kalaba, Emanuel Raschi (487410), Marion Bennie, Raschi Emanuel, Brian Godman, Kalaba, M. (Marija), Bennie Marion, Wettermark Bjorn, Raschi, Emanuel, Poluzzi, Elisabetta, Ugo Moretti, Elisabetta Poluzzi (487411), De Ponti, Fabrizio, Alfonso Carvajal, Marion Bennie (487416), Ugo Moretti (487414), Ariola Koci (487413), Moretti, Ugo, Wettermark, B. (Bjorn), Kalaba Marija, Poluzzi, E. (Elisabetta), Barbui C, Wettermark, Bjorn, Fabrizio De Ponti, Corrado Barbui (242747), Emanuel Raschi, Kalaba, Marija, Bennie, M. (Marion), Bennie M, Bjorn Wettermark (487417)   +62 more
core   +1 more source

Using ML to repurpose FDA drugs for the treatment of Diabetic Cardiomyopathy

, 2023
PARP-1 (Poly ADP Ribose polymerase) functions to repair damage to DNA and is implicated in a variety of diseases including Diabetic Cardiomyopathy (DCM).
Vishnu, Aravind, Alex, Kumar
core   +1 more source

Predicting Drug–Drug Interactions: An FDA Perspective [PDF]

The AAPS Journal, 2009
Pharmacokinetic drug interactions can lead to serious adverse events, and the evaluation of a new molecular entity's drug-drug interaction potential is an integral part of drug development and regulatory review prior to its market approval. Alteration of enzyme and/or transporter activities involved in the absorption, distribution, metabolism, or ...
Lei, Zhang, Yuanchao Derek, Zhang, Ping, Zhao, Shiew-Mei, Huang   +3 more
openaire   +2 more sources

Repurposing of FDA Approved Drugs for the Identification of Potential Inhibitors of SARS-CoV-2 Main Protease

, 2020
COVID-19, responsible for several deaths, demands a cumulative effort of scientists worldwide to curb the pandemic. The main protease, responsible for the cleavage of the polyprotein and formation of replication complex in virus, is considered as a ...
Satyaranjan, Biswal, Saroj Kumar, Panda, Abhik Kumar, Ray, Parth Sarthi Sen, Gupta, Malay Kumar, Rana   +4 more
core   +1 more source

Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections [PDF]

, 2016
Treatment options for infections with soil-transmitted helminths (STH) - Ascaris lumbricoides, Trichuris trichiura and the two hookworm species, Ancylostoma duodenale and Necator americanus - are limited despite their considerable global health burden ...
Ivan Scandale (349072), Jennifer Keiser, Mireille Vargas (392661), Ivan Scandale, Noemi Cowan, Adelfio, Roberto, Panic, Gordana, Gordana Panic, Roberto Adelfio, Cowan, Noemi, Gordana Panic (507685), Roberto Adelfio (392660), Keiser, Jennifer, Scandale, Ivan, Jennifer Keiser (39606), Vargas, Mireille, Noemi Cowan (507684), Mireille Vargas   +17 more
core   +1 more source

Inhibition of Aβ42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs [PDF]

, 2016
The formation of small Aβ42 oligomers has been implicated as a toxic species in Alzheimer disease (AD). In strong support of this hypothesis we found that overexpression of Yap1802, the yeast ortholog of the human AD risk factor, phosphatidylinositol ...
Maria Valencik, Ratia, Kiira, Liebman, Ba, Mariam A., Sei-Kyoung Park, Susan W. Liebman, Kiira Ratia, Mariam Ba, Park, Sei-Kyoung, Liebman, Susan W., Valencik, Maria L.   +10 more
core   +1 more source

Virtual Screening and binding mode analysis of selected FDA approved drugs against PLpro target: An effort to identify therapeutics to combat COVID-19

, 2023
Papain-like protease (PLpro) is one of the most promising targets for anti-SARS-CoV drugs. In this study, a bioactive library of FDA-approved drugs has virtually been screened using a new successful computational pipeline in the framework of the ensemble
Rohoullah , Firouzi, Mitra, Ashouri
core   +1 more source

Drugs, Devices, and the FDA: Part 2

JACC: Basic to Translational Science, 2016
As with new drugs, the U.S. Food and Drug Administration’s approval process is intended to provide consumers with assurance that, once it reaches the market place, a medical device is safe and effective in its intended use.
Gail A. Van Norman, MD
doaj   +1 more source

An update in drug use during pregnancy: risk classification [PDF]

Farmacia Hospitalaria, 2014
Objective: To review medicines pregnancy category and establish the degree of conformity between the two systems more used: FDA (Food and Drug Administration) and ACPM (advisory Committee on Prescription Medicines). Methods: drugs used in most frequent
M. Gallego Úbeda, L. Delgado Téllez de Cepeda, M.ª de los A. Campos Fernández de Sevilla, A. de Lorenzo Pinto, F. Tutau Gómez   +4 more
doaj   +1 more source

Suicidal behavior and antiepileptic drugs in epilepsy: analysis of the emerging evidence

, 2011
Marco Mula1, Dale C Hesdorffer21Department of Clinical and Experimental Medicine, Amedeo Avogadro University and Division of Neurology, University Hospital Maggiore della Carità, Novara, Italy; 2Gertrude H Sergievsky Center and Department of ...
Mula M, Mula, M, Hesdorffer DC, Hesdorffer, DC   +3 more
core   +1 more source