Results 51 to 60 of about 4,580,673 (328)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Los profetas, Jesús y lo social

Ideas y Valores, 1972
En la actualidad son abundantes los estudios sobre el problema religioso percibido y analizado dentro de unos marcos más amplios que los ofrecidos hasta hace poco por la crítica clásica de la religión.
Alfonso Rincón González
doaj  

Spatial and temporal trends of iron and iron isotope cycling in the Peruvian oxygen minimum zone [PDF]

, 2012
Iron (Fe) is a key element in the global ocean’s biogeochemical framework because of its essential role in numerous biological processes. A poorly studied link in the oceanic Fe cycle is the reductive release of Fe from sediments in oxygen depleted ocean
Haley, Brian, Hensen, Christian, McManus, James, Noffke, Anna, Schneider, Ralph, Scholz, Florian, Severmann, Silke, Wallmann, Klaus   +7 more
core  

Iron isotope effect on the superconducting transition temperature and the crystal structure of FeSe_1-x [PDF]

, 2010
The Fe isotope effect (Fe-IE) on the transition temperature T_c and the crystal structure was studied in the Fe chalcogenide superconductor FeSe_1-x by means of magnetization and neutron powder diffraction (NPD).
, Bussmann-Holder A Simon A Keller H Bishop A R, E Pomjakushina, H Keller, K Conder, Khasanov R, M Bendele, Margadonna S, Mizuguchi Y, R Khasanov, V Pomjakushin   +10 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Calculated oscillation periods of the interlayer coupling in Fe/Cr/Fe and Fe/Mo/Fe sandwiches [PDF]

Physical Review B, 1996
We have performed an ab initio study of the oscillation periods of the interlayer coupling in sandwiches of [100] layers of body centered cubic Cr, respectively, Mo, with up to 20 monolayers thickness embedded in an Fe host. Our derived values for the oscillation periods of the interlayer coupling agree well with those expected from the respective ...
Mirbt, S., Niklasson, A.M.N., Johansson, B., Skriver, Hans Lomholt   +3 more
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Two distinct halo populations in the solar neighborhood. II. Evidence from stellar abundances of Mn, Cu, Zn, Y, and Ba

, 2011
A previous study (Nissen & Schuster 2010) of 94 dwarf stars with -1.6 < [Fe/H] < -0.4 has revealed the existence of two distinct halo populations with a systematic difference in [alpha/Fe] at a given metallicity.
Anstee, Asplund, Badenes, Barklem, Barklem, Bekki, Bensby, Bergemann, Bergemann, Bisterzo, Busso, Carretta, Carretta, Cescutti, Chou, Chou, Cohen, Cohen, Collet, Cunha, Cunha, Dinescu, D’Ercole, Feltzing, Fenner, Freeman, Fulbright, Gratton, Gratton, Gustafsson, Hannaford, Helmi, Ishigaki, Johnson, Jonsell, Kaufer, Keller, Klement, Kobayashi, Kobayashi, Koch, Korn, Lanfranchi, Latham, Letarte, Maoz, McWilliam, McWilliam, McWilliam, Meza, Nissen, Nissen, Nissen, Nomoto, Origlia, P. E. Nissen, Pancino, Pompéia, Prochaska, Purcell, Qu, Sbordone, Schaller, Schuster, Smith, Sneden, Stephens, Takeda, Tautvaišiene, Tinsley, Tolstoy, Travaglio, Tsujimoto, Venn, Ventura, W. J. Schuster, Woosley, Zolotov, Zolotov   +78 more
core   +1 more source

Abundance patterns in early-type galaxies: is there a 'knee' in the [Fe/H] vs. [alpha/Fe] relation? [PDF]

, 2015
Early-type galaxies (ETGs) are known to be enhanced in alpha elements, in accordance with their old ages and short formation timescales. In this contribution we aim to resolve the enrichment histories of ETGs. This means we study the abundance of Fe ([Fe/
Bruzual, G., Charlot, S., Chiappini, C., Coelho, P. R. T., Gallazzi, A., Walcher, C. J.   +5 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source