Results 61 to 70 of about 5,406,738 (330)

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Miguel de Unamuno, tragedia y esperanza. ¿Qué debemos hacer y qué podemos esperar?

Valenciana, 2009
From Miguel de Unamuno´s perspective, we would be left with no more than a quixotic faith dying in the face of the finite and contingent condition of life —caught up in tragedy and hope. Analyzing this kind of pragmatic creative vitalism, this paper aims
José Mendívil Macías Valadez
doaj   +1 more source

Carbon-enhanced Metal-poor Stars in SDSS/SEGUE. I. Carbon Abundance Estimation and Frequency of CEMP Stars

, 2013
We describe a method for the determination of stellar [C/Fe] abundance ratios using low-resolution (R = 2000) stellar spectra from the SDSS and SEGUE. By means of a star-by-star comparison with a set of SDSS/SEGUE spectra with available estimates of [C ...
Beers, Timothy C., Carollo, Daniela, Lee, Young Sun, Lucatello, Sara, Masseron, Thomas, Placco, Vinicius M., Plez, Bertrand, Rockosi, Constance M., Sivarani, Thirupathi, Sobeck, Jennifer, Yanny, Brian   +10 more
core   +3 more sources

Facile Synthesis of Atomic Fe‐N‐C Materials and Dual Roles Investigation of Fe‐N4 Sites in Fenton‐Like Reactions

Advancement of science, 2021
Fenton‐like reactions with persulfates as the oxidants have attracted increasing attentions for the remediation of emerging antibiotic pollutions. However, developing effective activators with outstanding activities and long‐term stabilities remains a ...
J. Wang, Bin Li, Yang Li, Xiaobin Fan, Feng-bao Zhang, Guoliang Zhang, W. Peng   +6 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

KIERKEGAARD-DERRIDA Y LA RECONSTRUCCIÓN DEL SUJETO

Daimon, 2007
En Temor y temblor, Søren Kierkegaard evoca la bíblica figura de Abraham, con motivo de ilustrar su concepción del individuo. Del mismo modo Jacques Derrida, en Dar la muerte, retoma el texto kierkegaardiano, a fin de descubrir el sentido de la ...
María J. Binetti
doaj  

Lisboa y el fin de las teodiceas. El mal entre la confianza y el dolor

Theoría Revista del Colegio de Filosofía, 2019
El presente texto realiza un breve recorrido a través de distintas posturas filosóficas que sostienen o critican teodiceas en la modernidad. En cada una de ellas se ensalza el papel de la fe entendida como confianza filial y el mal físico o dolor, y la ...
Carlos David García Mancilla
doaj   +1 more source

Nucleosynthesis in Type II supernovae and the abundances in metal-poor stars [PDF]

, 1998
We explore the effects on nucleosynthesis in Type II supernovae of various parameters (mass cut, neutron excess, explosion energy, progenitor mass) in order to explain the observed trends of the iron-peak element abundance ratios ([Cr/Fe], [Mn/Fe], [Co ...
Adam Burrows, Barbuy B., Edvardsson B., Friedrich‐Karl Thielemann, Gratton R. G., Gratton R. G., Gratton R. G., Gratton R. G., Hashimoto M., Hideyuki Umeda, Ken'ichi Nomoto, Magain P., Molaro P., Molaro P., Nissen P. E., Nomoto K., Primas F., Schaller G., Shigeyama T., Takayoshi Nakamura, Tsujimoto T., Zhao G.   +21 more
core   +4 more sources

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

LA INFLUENCIA DE KIERKEGAARD EN LA RECONSTRUCCIÓN DE LA SUBJETIVIDAD POSMODERNA

Praxis Filosófica, 2011
Así como hay una lectura de la subjetividad posmoderna entendida en los términos de un nihilismo relativista y ateo, hay también otra lectura de la misma en los términos de una determinación absoluta y divina, inconmensurable e infnita, cuyo exceso de ...
María J. Binetti
doaj   +1 more source