Results 61 to 70 of about 1,035,858 (286)

Cape Fear Ford

Reproduction of a photograph of the Cape Fear Ford dealership near Market Street and Second Street in downtown Wilmington.

core   +3 more sources

Functional vulnerability and all-cause mortality among community-dwelling United States adults with a history of hepatitis or chronic liver disease

iLIVER
Background and aims: Frailty predicts death in advanced cirrhosis and among transplant candidates, but whether a frailty-like functional index identifies mortality risk in the far larger population of community-dwelling adults with liver disease, who are
Chukwuemeka E. Ogbu, Ifeanyi Momodu, Philip N. Okafor   +2 more
doaj   +1 more source

Alternative uses for tannery wastes: a review of environmental, sustainability, and science

Journal of Leather Science and Engineering, 2020
The manufacture of leather covers a wide productive chain and beyond contributes to the economic flow. The various stages of leather processing result in high volumes of solid waste.
Cesar Vinicius Toniciolli Rigueto, Marieli Rosseto, Daniela Dal Castel Krein, Bruna Elisangela Pessini Ostwald, Lillian Avila Massuda, Bárbara Belém Zanella, Aline Dettmer   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Social isolation and loneliness: an integration framework for medical education

Frontiers in Medicine
Loneliness and social isolation are increasingly recognized as critical public health issues, linked to adverse outcomes such as cardiovascular disease, cognitive decline, depression, and increased healthcare utilization.
Jerlinda G. C. Ross, Veronica Escamilla, Carrie Elzie   +2 more
doaj   +1 more source

Don't fear 'fear conditioning'

Neuroscience and Biobehavioral Reviews, 2017
The so-called 'replicability crisis' has sparked methodological discussions in many areas of science in general, and in psychology in particular. This has led to recent endeavours to promote the transparency, rigour, and ultimately, replicability of research.
Lonsdorf, Tina B., Menz, Mareike M., Andreatta, Marta, Fullana, Miguel A., Golkar, Armita, Haaker, Jan, Heitland, Ivo, Hermann, Andrea, Kuhn, Manuel, Kruse, Onno, Meir Drexler, Shira, Meulders, Ann, Nees, Frauke, Pittig, Andre, Richter, Jan, Römer, Sonja, Shiban, Youssef, Schmitz, Anja, Straube, Benjamin, Vervliet, Bram, Wendt, Julia, Baas, Johanna M.P., Merz, Christian J.   +22 more
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Dram Tree on the Cape Fear River

Photograph of the Dram Tree (left) on the Cape Fear ...

core   +2 more sources

Intestinal-type adenocarcinoma of the vulva: A case study

Gynecologic Oncology Reports, 2019
Approximately 5% of all gynecologic cancers are of the vulva, of which 90% are squamous cell in origin. Adenocarcinomas of the vulva are extremely infrequent with most relating to epithelial glands in the vulvar region.
Brian Kaltenecker, Robert Manos, Meagan McCall, Paul Sparzak   +3 more
doaj   +1 more source