Results 31 to 40 of about 19,755 (259)
Nicotine and extinction of fear conditioning [PDF]
Neuroscience, 2010 Despite known health risks, nicotine use remains high, especially in populations diagnosed with mental illnesses, including anxiety disorders and Post-Traumatic Stress Disorder (PTSD). Smoking in these populations may relate to the effects of nicotine on emotional memories.
G A, Elias +3 more
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Pattern separation of fear extinction memory
Learning & Memory, 2023 While fear generalizes widely, extinction is stimulus-specific. Using a hybrid conditioning/episodic memory paradigm, subjects encoded nonrepeating category exemplars during fear conditioning and extinction. Twenty-four hours later, a surprise memory test included old, similar, and novel category exemplars.
Patrick A.F. Laing, Joseph E. Dunsmoor
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Social Company by a Receptive Mating Partner Facilitates Fear Extinction
Frontiers in Neuroscience, 2020 Fear extinction remains an unresolved challenge for behavioral exposure therapy in patients with post-traumatic stress disorder (PTSD). Previous reports have suggested that social support from either familiar or unfamiliar same-sex partners is beneficial
Feng Gao +12 more
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HDAC1 Regulates Fear Extinction in Mice [PDF]
The Journal of Neuroscience, 2012 Histone acetylation has been implicated with the pathogenesis of neuropsychiatric disorders and targeting histone deacetylases (HDACs) using HDAC inhibitors was shown to be neuroprotective and to initiate neuroregenerative processes. However, little is known about the role of individual HDAC proteins during the pathogenesis of brain diseases. HDAC1 was
Bahari-Javan, Sanaz +10 more
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Berberine Facilitates Extinction and Prevents the Return of Fear
Frontiers in Pharmacology, 2022 Exposure to a catastrophic event or intense stimulation can trigger fear memories, and the threatening memories persist even over a lifetime. Exposure therapy is based on extinction learning and is widely used to treat fear-related disorders, but its ...
Shihao Huang +9 more
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Fear extinction learning modulates large-scale brain connectivity
NeuroImage, 2021 Exploring the neural circuits of the extinction of conditioned fear is critical to advance our understanding of fear- and anxiety-related disorders. The field has focused on examining the role of various regions of the medial prefrontal cortex, insular ...
Zhenfu Wen +2 more
doaj +1 more source
Rodent models of impaired fear extinction [PDF]
Psychopharmacology, 2018 The measurement of Pavlovian forms of fear extinction offers a relatively simple behavioral preparation that is nonetheless tractable, from a translational perspective, as an approach to study mechanisms of exposure therapy and biological underpinnings of anxiety and trauma-related disorders such as post-traumatic stress disorder (PTSD). Deficient fear
Nicolas Singewald, Andrew Holmes
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Basic and Clinical Neuroscience, 2022 Introduction: The basolateral amygdala (BLA) and infralimbic area (IL) of the medial prefrontal cortex (mPFC) are two interconnected brain structures that mediate both fear memory expression and extinction.
Abbas Ali Vafaei +4 more
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Neurobiology of Stress, 2021 Impaired extinction of conditioned fear is associated with anxiety disorders. Common lifestyle factors, like isolation stress and exercise, may alter the ability to extinguish fear. However, the effect of and interplay between these factors on adolescent
Katherine D. Drummond +5 more
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Extending Fear Extinction Beyond Anxiety Disorders [PDF]
Biological Psychiatry, 2009 “Nothing in life is to be feared, it is only to be understood.” This encouraging statement by Marie Curie in the early 1900s holds new meaning given the current interest in extinction of conditioned fear in psychiatry. Decades of experimental psychology in both animals and humans have shown that stimuli paired with an aversive outcome such as electric ...
Karen G, Martínez, Gregory J, Quirk
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