Results 11 to 20 of about 637,566 (254)
Frontiers in Synaptic Neuroscience, 2021 The ability to extinguish fear memories when threats are no longer present is critical for adaptive behavior. Fear extinction represents a new learning process that eventually leads to the formation of extinction memories.
Ximena I. Salinas-Hernández +1 more
doaj +2 more sources
Central amygdala micro-circuits mediate fear extinction [PDF]
, 2021 The central amygdala inhibitory microcircuits mediate fear extinction by reversible, stimulus- and context-specific changes in neuronal responses. These alterations are absent when extinction is deficient and selective silencing of PKCδ neurons impairs ...
Jonathan Fadok +39 more
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Inhibition of Diacylglycerol Lipase Impairs Fear Extinction in Mice
Frontiers in Neuroscience, 2018 Elucidating the underlying molecular mechanisms regulating fear and extinction learning may offer insights that can lead to novel treatments for debilitating anxiety and trauma-related disorders including posttraumatic stress disorder.
Victoria S. Cavener +8 more
doaj +2 more sources
Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala. [PDF]
, 2023 Extinction memory retrieval is influenced by spatial contextual information that determines responding to conditioned stimuli (CS). However, it is poorly understood whether contextual representations are imbued with emotional values to support memory ...
Koukoutselos, Konstantinos +3 more
core +2 more sources
Explaining the effectiveness of fear extinction through latent-cause inference
, 2021 Acquiring fear responses to predictors of aversive outcomes is crucial for survival. At the same time, it is important to be able to modify such associations when they are maladaptive, for instance in treating anxiety and trauma-related disorders ...
Marie-H. Monfils +3 more
core +1 more source
Differential activation of anatomically defined neuronal subpopulations in the amygdala during fear conditioning and extinction [PDF]
, 2009 The amygdala is a key structure of the neuronal circuitry mediating expression and extinction of conditioned fear. However, fear memories are thought to be encoded in a larger network comprising the medial prefrontal cortex (mPFC) and the ...
Senn, Verena
core +1 more source
Fear conditioning- and extinction-induced neuronal plasticity in the mouse amygdala [PDF]
, 2009 Experience-dependent changes in behavior are mediated by long-term functional modifications in brain circuits. To study the underlying mechanisms, our lab is using classical auditory fear conditioning, a simple and robust form of associative learning. In
Ciocchi, Stéphane
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Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval
Frontiers in Psychology, 2017 Disruption of fear conditioning, its extinction and its retrieval are at the core of posttraumatic stress disorder (PTSD). Such deficits, especially fear extinction delay, disappear after alternating bilateral stimulations (BLS) during eye movement ...
Sarah Boukezzi +10 more
doaj +1 more source
Neurobiology of Stress, 2021 The nucleus accumbens (NAc), consisting of core (NAcC) and shell (NAcS) sub-regions, has primarily been studied as a locus mediating the effects of drug reward and addiction.
Sohini Dutta +3 more
doaj +1 more source
The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans [PDF]
, 2009 Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)- type glutamate receptors.
Dolan, RJ +21 more
core +1 more source