GluN2D NMDA Receptors Gate Fear Extinction Learning and Interneuron Plasticity [PDF]
Frontiers in Synaptic Neuroscience, 2021 The cerebellum is critically involved in the formation of associative fear memory and in subsequent extinction learning. Fear conditioning is associated with a long-term potentiation at both excitatory and inhibitory synapses onto Purkinje cells.
Christophe J. Dubois +2 more
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A proof-of-concept study of vicarious extinction learning and autonomic synchrony in parent–child dyads and posttraumatic stress disorder [PDF]
Scientific Reports, 2023 Though threat-extinction models continue to inform scientific study of traumatic stress, knowledge of learning and extinction as mechanisms linking exposure to psychopathology remains critically limited among youth.
Sara A. Heyn +7 more
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Transcriptomic Architecture of Weak Versus Strong Contextual Fear Extinction Learning Uncovers Extinction-Suppressive Role of TIA1 [PDF]
Biological Psychiatry Global Open ScienceBackground: Extinction, the capacity for an individual to inhibit or diminish fear memories, is a critical aspect of fear processing. In humans, weak extinction learning is often observed in anxiety and fear-related disorders such as posttraumatic stress
Maria I. Bonilla +4 more
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Exogenous glucocorticoids to improve extinction learning for post-traumatic stress disorder patients with hypothalamic–pituitary–adrenal-axis dysregulation: a study protocol description [PDF]
European Journal of PsychotraumatologyBackground: Trauma-focused treatments for post-traumatic stress disorder (PTSD) are effective for many patients. However, relapse may occur when acquired extinction memories fail to generalize beyond treatment contexts.
Laura de Nooij +7 more
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Neural correlates of appetitive extinction learning: an fMRI study with actively participating pigeons [PDF]
Scientific ReportsExtinction learning is an important learning process that enables adaptive and flexible behavior. Human neuroimaging studies show that the neural basis of extinction learning consists of a neural network that includes the hippocampus, amygdala, and ...
Mehdi Behroozi +5 more
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Microstructural differences in the cingulum and the inferior longitudinal fasciculus are associated with (extinction) learning [PDF]
BMC PsychologyCognitive functions, such as learning and memory processes, depend on effective communication between brain regions which is facilitated by white matter tracts (WMT).
Alina Nostadt +6 more
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Life, 2022 Stress induces neuroinflammation and disrupts sleep, which together can promote a number of stress-related disorders. Fear memories associated with stress can resurface and reproduce symptoms.
Austin M. Adkins +2 more
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Frontiers in Behavioral Neuroscience, 2021 Brain derived neurotropic factor (BDNF) supports neuronal survival, growth, and differentiation and is involved in forms of hippocampus-dependent and independent learning, as well as hippocampus-dependent learning.
Marta Méndez-Couz +2 more
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BEHAVIORAL AND NEUROBIOLOGICAL MECHANISMS OF PAVLOVIAN AND INSTRUMENTAL EXTINCTION LEARNING.
Physiol Rev, 2021 Bouton ME, Maren S, McNally GP.
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The Neurocircuitry Underlying Additive Effects of Safety Instruction on Extinction Learning
Frontiers in Behavioral Neuroscience, 2021 Extinction learning is the dominant laboratory model for exposure therapy, a treatment involving both experience of safety near the feared object, and safety instructions relayed by a therapist.
Arash Javanbakht +5 more
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