Results 1 to 10 of about 637,566 (254)

Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction

Cell Reports, 2023
Summary: Fear-related disorders arise from inefficient fear extinction and have immeasurable social and economic costs. Here, we characterize mouse phenotypes that spontaneously show fear-independent behavioral traits predicting adaptive or maladaptive ...
Daniela Laricchiuta, Juliette Gimenez, Giuseppe Sciamanna, Andrea Termine, Carlo Fabrizio, Francesco Della Valle, Silvia Caioli, Luana Saba, Marco De Bardi, Francesca Balsamo, Anna Panuccio, Noemi Passarello, Anna Mattioni, Elisa Bisicchia, Cristina Zona, Valerio Orlando, Laura Petrosini   +16 more
doaj   +2 more sources

Enhancing fear extinction. [PDF]

Elife
Gradually reducing a source of fear during extinction treatments may weaken negative memories in the long term.
Trask S, Ferrara NC.
europepmc   +2 more sources

Fear extinction retention in children, adolescents, and adults. [PDF]

Dev Cogn Neurosci
Past results suggest that fear extinction and the return of extinguished fear are compromised in adolescents. However, findings have been inconclusive as there is a lack of fear extinction and extinction retention studies including children, adolescents ...
Widegren E, Vegelius J, Frick MA, Roy AA, Möller S, Kleberg JL, Hoppe JM, Hjorth O, Fällmar D, Pine DS, Brocki K, Gingnell M, Frick A.   +12 more
europepmc   +2 more sources

Transcriptomic Architecture of Weak Versus Strong Contextual Fear Extinction Learning Uncovers Extinction-Suppressive Role of TIA1. [PDF]

Biol Psychiatry Glob Open Sci
Background: Extinction, the capacity for an individual to inhibit or diminish fear memories, is a critical aspect of fear processing. In humans, weak extinction learning is often observed in anxiety and fear-related disorders such as posttraumatic stress
Bonilla MI, Lee HL, Foster S, Kim IJ, Rudenko A.   +4 more
europepmc   +2 more sources

Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice. [PDF]

Transl Psychiatry
Psychopharmacotherapy is often used to treat anxiety- and stress-associated psychiatric disorders, including post-traumatic stress disorder (PTSD). Adjunctive therapy is most typically used with medications that influence serotonin balance, such as ...
Schulte H, Böke H, Lössl P, Worm M, Siveke I, Herlitze S, Spoida K.   +6 more
europepmc   +2 more sources

A neurally constrained computational model of context-dependent fear extinction recall and relapse. [PDF]

Commun Biol
Exposure therapy, a standard treatment for anxiety disorders, relies on fear extinction. However, extinction recall is often limited to the spatial and temporal context in which extinction is learned, leading to fear relapse in new settings or after ...
Rajagopal SK, Polk TA.
europepmc   +2 more sources

Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats

Frontiers in Pharmacology, 2022
Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can enhance extinction,
William G. Warren, Eleni P. Papagianni, Ed Hale, Rebecca A. Brociek, Helen J. Cassaday, Carl W. Stevenson   +5 more
doaj   +1 more source

Starting fear is a stronger predictor of long-term fear than rate of change in fear in human fear conditioning

Journal of Experimental Psychopathology, 2022
In rodent studies, faster extinction rate has been shown to predict less long-term fear. However, this has scarcely been studied in humans. The present report investigated the association between extinction rate and long-term fear in humans.
Tomislav D. Zbozinek, Alexandra S. Tanner, Michelle G. Craske   +2 more
doaj   +1 more source

Unrelenting Fear Under Stress: Neural Circuits and Mechanisms for the Immediate Extinction Deficit

Frontiers in Systems Neuroscience, 2022
Therapeutic interventions for disorders of fear and anxiety rely on behavioral approaches that reduce pathological fear memories. For example, learning that threat-predictive stimuli are no longer associated with aversive outcomes is central to the ...
Stephen Maren
doaj   +1 more source

Effects of 3,4-Methylenedioxymethamphetamine on Conditioned Fear Extinction and Retention in a Crossover Study in Healthy Subjects

Frontiers in Pharmacology, 2022
Background: 3,4-Methylenedioxymethamphetamine (MDMA) has shown initial promise as an adjunct in psychotherapy to treat posttraumatic stress disorder (PTSD). Its efficacy and safety have been demonstrated across phase I–III studies. However, the mechanism
Patrick Vizeli, Patrick Vizeli, Patrick Vizeli, Isabelle Straumann, Isabelle Straumann, Urs Duthaler, Urs Duthaler, Nimmy Varghese, Nimmy Varghese, Anne Eckert, Anne Eckert, Martin P. Paulus, Victoria Risbrough, Victoria Risbrough, Matthias E. Liechti, Matthias E. Liechti   +15 more
doaj   +1 more source