Results 21 to 30 of about 637,566 (254)

Presentation of unpaired unconditional stimuli during extinction reduces renewal of conditional fear and slows re‐acquisition

, 2021
Past research has shown that presenting unconditional stimuli (US) during extinction training, either paired with the conditional stimulus (CS) or explicitly unpaired, can reduce spontaneous recovery and slow the re-acquisition of conditional fear ...
Ryan, Katherine M, Camilla C. Luck, Waters, Allison M, Ottmar V. Lipp, Craske, Michelle G, Michelle G. Craske, Luck, Camilla C, Katherine M. Ryan, Allison M. Waters, Lipp, Ottmar   +9 more
core   +1 more source

Fear memory formation can affect a different memory: fear conditioning affects the extinction, but not retrieval, of conditioned taste aversion (CTA) memory

Frontiers in Behavioral Neuroscience, 2014
The formation of fear memory to a specific stimulus leads to subsequent fearful response to that stimulus. However, it is not known whether the formation of fear memory can affect other memories.
Gil eJoels, Raphael eLamprecht
doaj   +1 more source

Fear extinction learning ability predicts neuropathic pain behaviors and amygdala activity in male rats

Molecular Pain, 2018
Background The amygdala plays a key role in fear learning and extinction and has emerged as an important node of emotional-affective aspects of pain and pain modulation.
Guangchen Ji, Vadim Yakhnitsa, Takaki Kiritoshi, Peyton Presto, Volker Neugebauer   +4 more
doaj   +1 more source

Amygdala-ventral striatum circuit activation decreases long-term fear

eLife, 2016
In humans, activation of the ventral striatum, a region associated with reward processing, is associated with the extinction of fear, a goal in the treatment of fear-related disorders.
Susana S Correia, Anna G McGrath, Allison Lee, Ann M Graybiel, Ki A Goosens   +4 more
doaj   +1 more source

Systemic Cellular Activation Mapping of an Extinction-Impaired Animal Model

Frontiers in Cellular Neuroscience, 2019
Fear extinction diminishes conditioned fear responses and impaired fear extinction has been reported to be related to anxiety disorders such as post-traumatic stress disorder (PTSD).
Kwanghoon Park, ChiHye Chung
doaj   +1 more source

The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory [PDF]

, 2011
MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related ...
Vikram S Ratnu, Baker-Andresen, Danay, Kobor, Michael S, Zoran Boskovic, Timothy W Bredy, Coelho, Carlos M, Boskovic, Zoran, Wei, Wei, Danay Baker-Andresen, Carlos M Coelho, Xiang Li, Lin, Quan, Ratnu, Vikram S, Bredy, Timothy W, Kevin Dudley, Yi E Sun, Michael S Kobor, Wei Wei, Li, Xiang, Dudley, Kevin, Sun, Yi E, Quan Lin   +21 more
core   +1 more source

Orexin A Differentially Influences the Extinction Retention of Recent and Remote Fear Memory

Frontiers in Neuroscience, 2018
Recently the role of the orexin system in the learning and memory, especially orexin A, which could enhance fear memory through regulating the activity of amygdala, has drawn considerable attention.
Le Shi, Le Shi, Wenhao Chen, Jiahui Deng, Sijing Chen, Ying Han, Muhammad Z. Khan, Muhammad Z. Khan, Jiajia Liu, Jiajia Liu, Jianyu Que, Yanping Bao, Lin Lu, Lin Lu, Lin Lu, Jie Shi   +15 more
doaj   +1 more source

Spontaneous recovery of fear reverses extinction-induced excitability of infralimbic neurons.

PLoS ONE, 2014
In rodents, the infralimbic (IL) region of the medial prefrontal cortex plays a key role in the recall of fear extinction. Previously we showed that fear conditioning decreases the intrinsic excitability of IL neurons, and that fear extinction reverses ...
Emmanuel Cruz, Ana V López, James T Porter   +2 more
doaj   +1 more source

Theta coupling within the medial prefrontal cortex regulates fear extinction and renewal

iScience, 2022
Summary: Fear learning, and its extinction, are fundamental learning processes that allow for a response adaptation to aversive events and threats in the environment.
Cong Wang, Peter G. Stratton, Pankaj Sah, Roger Marek   +3 more
doaj   +1 more source

Retrieval and Reconsolidation Accounts of Fear Extinction [PDF]

, 2016
Extinction is the primary mode for the treatment of anxiety disorders. However, extinction memories are prone to relapse. For example, fear is likely to return when a prolonged time period intervenes between extinction and a subsequent encounter with the
Jeannie Huang, Wolvek, David, Michael Merjanian, Irina Zhuravka, Justin Shobe, Ponnusamy, Ravikumar, Poulos, Andrew M, Fanselow, Michael S, Pia-Kelsey O’Neill, Merjanian, Michael, Michael S. Fanselow, Andrew M. Poulos, David Wolvek, O’Neill, Pia-Kelsey, Shobe, Justin, Ravikumar Ponnusamy, Zhuravka, Irina, Huang, Jeannie   +17 more
core   +1 more source