Results 31 to 40 of about 167,189 (259)

Theta coupling within the medial prefrontal cortex regulates fear extinction and renewal

iScience, 2022
Summary: Fear learning, and its extinction, are fundamental learning processes that allow for a response adaptation to aversive events and threats in the environment.
Cong Wang, Peter G. Stratton, Pankaj Sah, Roger Marek   +3 more
doaj   +1 more source

Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning

Frontiers in Behavioral Neuroscience, 2019
The olfactory bulb (OB) receives significant cholinergic innervation and widely expresses cholinergic receptors. While acetylcholine (ACh) is essential for olfactory learning, the exact mechanisms by which ACh modulates olfactory learning and whether it ...
Jordan M. Ross, Mounir Bendahmane, Max L. Fletcher   +2 more
doaj   +1 more source

Mechanisms underlying contextual fear learning [PDF]

Communicative & Integrative Biology, 2011
The hippocampus plays a central role in learning and memory. Although synaptic delivery of AMPA-type glutamate receptors (AMPARs) contributes to experience-dependent synaptic strengthening, its role in hippocampus-dependent learning remains elusive. In a recent study,we found that the inhibitory avoidance (IA) task, a hippocampus-dependent contextual ...
openaire   +2 more sources

Serotonin Deficiency Increases Context-Dependent Fear Learning Through Modulation of Hippocampal Activity

Frontiers in Neuroscience, 2019
Brain serotonin (5-hydroxytryptamine, 5-HT) system dysfunction is implicated in exaggerated fear responses triggering various anxiety-, stress-, and trauma-related disorders. However, the underlying mechanisms are not well understood.
Jonas Waider, Sandy Popp, Boris Mlinar, Alberto Montalbano, Francesco Bonfiglio, Benjamin Aboagye, Elisabeth Thuy, Raphael Kern, Christopher Thiel, Naozumi Araragi, Naozumi Araragi, Evgeniy Svirin, Evgeniy Svirin, Angelika G. Schmitt-Böhrer, Renato Corradetti, Christopher A. Lowry, Klaus-Peter Lesch, Klaus-Peter Lesch, Klaus-Peter Lesch   +18 more
doaj   +1 more source

GluN2D NMDA Receptors Gate Fear Extinction Learning and Interneuron Plasticity

Frontiers in Synaptic Neuroscience, 2021
The cerebellum is critically involved in the formation of associative fear memory and in subsequent extinction learning. Fear conditioning is associated with a long-term potentiation at both excitatory and inhibitory synapses onto Purkinje cells.
Christophe J. Dubois, Siqiong June Liu, Siqiong June Liu   +2 more
doaj   +1 more source

Updating appetitive memory during reconsolidation window: critical role of cue-directed behavior and amygdala central nucleus.

Frontiers in Behavioral Neuroscience, 2013
When presented with a light cue followed by food, some rats simply approach the foodcup (Nonorienters), while others first orient to the light in addition to displaying the food-cup approach behavior (Orienters).
Megan E Olshavsky, Bryan eSong, Daniel J Powell, Carolyn E Jones, Marie H Monfils, Marie H Monfils, Hongjoo Joanne Lee   +6 more
doaj   +1 more source

Blood pressure variations real-time reflect the conditioned fear learning and memory. [PDF]

PLoS ONE, 2012
The conditioned fear learning and memory occurs when a neutral conditioned stimulus (CS) is paired with an aversive unconditioned stimulus (US). This process is critically dependent on the amygdala and inevitably involves blood pressure (BP) alterations.
Yuan-Chang Hsu, Lung Yu, Hsiun-ing Chen, Hui-Ling Lee, Yu-Min Kuo, Chauying J Jen   +5 more
doaj   +1 more source

Neurofunctional predictive biomarkers of cognitive-behavioral therapy during fear conditioning in patients with obsessive-compulsive disorder

European Psychiatry, 2021
Introduction Altered fear learning processes could be mechanistically linked to the development and/or maintenance of obsessive-compulsive disorder (OCD).
M. Cano-Catala, I. Martinez-Zalacain, E. Real, P. Alonso, J.M. Menchon, N. Cardoner Álvarez, M.A. Fullana, C. Soriano-Mas   +7 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Auditory stimuli suppress contextual fear responses in safety learning independent of a possible safety meaning

Frontiers in Behavioral Neuroscience
Safety learning allows the identification of non-threatening situations, a learning process instrumental for survival and psychic health. In contrast to fear learning, in which a sensory cue (conditioned stimulus, CS) is temporally linked to a mildly ...
Elena Mombelli, Denys Osypenko, Shriya Palchaudhuri, Christos Sourmpis, Christos Sourmpis, Johanni Brea, Olexiy Kochubey, Ralf Schneggenburger   +7 more
doaj   +1 more source