Results 111 to 120 of about 2,304,658 (297)

Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress

open access: yeseLife, 2018
Glucocorticoid receptor (GR) is crucial for signaling mediated by stress-induced high levels of glucocorticoids. The lateral nucleus of the amygdala (LA) is a key structure underlying auditory-cued fear conditioning.
Ran Inoue   +6 more
doaj   +1 more source

Spermidine improves fear memory persistence

open access: yesEuropean Journal of Pharmacology, 2014
Persistence is the most characteristic attribute of long-term memory (LTM). For memory persistence, a second late event of consolidation, that occurs around 12h after the acquisition, is necessary. Although the N-methyl-d-aspartate (NMDA) receptor has been involved in the persistence of memory, whether endogenous modulators of the NMDA receptor ...
Signor, Cristiane   +4 more
openaire   +2 more sources

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali   +4 more
wiley   +1 more source

Role of Amygdala-Infralimbic Cortex Circuitry in Glucocorticoid-induced Facilitation of Auditory Fear Memory Extinction

open access: yesBasic and Clinical Neuroscience, 2022
Introduction: The basolateral amygdala (BLA) and infralimbic area (IL) of the medial prefrontal cortex (mPFC) are two interconnected brain structures that mediate both fear memory expression and extinction.
Abbas Ali Vafaei   +4 more
doaj  

City of fear

open access: yes, 2017
Urban problems have roots in much more abstract issues than only urban design. To understand this, we must cross the approaches of sociologists, politicians, historians, psychologists or criminologists, to name a few.
City of Fear
core  

Fear memory networks have small-world structure.

open access: yes, 2013
A. Histogram showing degree distribution for fear memory networks corresponding to the 1 day (upper) and 36 day (lower) retention delay. B. Mean clustering coefficient for fear memory vs. random network.
Natasa Kovacevic (105666)   +8 more
core   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram   +3 more
wiley   +1 more source

Structural plasticity of synaptic connectivity in the adult hippocampal mossy fiber projection [PDF]

open access: yes, 2013
The brain has the lifelong ability to change itself based on new experiences such as learning and memory. This so called neuronal plasticity is reflected in the brain by structural and functional modifications which underlie our ability to learn ...
Ruediger, Sarah
core   +1 more source

Reserves, Injury Severity, and Outcomes in Traumatic Brain Injury: A CENTER‐TBI Observational Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Reserve refers to the brain's ability to maintain function after an injury and strongly relates to traumatic brain injury (TBI) outcomes. This study examined (1) whether associations between pre‐injury reserve proxies and outcomes differed across injury severity categories, and (2) whether the impact of injury severity varied across ...
Natascha Ekdahl   +6 more
wiley   +1 more source

Fear renewal activates cyclic adenosine monophosphate signaling in the dentate gyrus

open access: yesBrain and Behavior, 2019
Background Fear renewal, the context‐specific relapse of a conditioned fear after extinction, is a widely pursued model of post‐traumatic stress disorder and phobias. However, its cellular and molecular mechanisms remain poorly understood.
Yan-Wei Shi   +4 more
doaj   +1 more source

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