Results 1 to 10 of about 8,759 (205)

A model of synaptic reconsolidation [PDF]

open access: yesFrontiers in Neuroscience, 2016
Reconsolidation of memories has mostly been studied at the behavioral and molecular level. Here, we put forward a simple extension of existing computational models of synaptic consolidation to capture hippocampal slice experiments that have been ...
David B. Kastner   +4 more
doaj   +7 more sources

The Mechanisms and Boundary Conditions of Drug Memory Reconsolidation

open access: yesFrontiers in Neuroscience, 2021
Drug addiction can be seen as a disorder of maladaptive learning characterized by relapse. Therefore, disrupting drug-related memories could be an approach to improving therapies for addiction.
Liangpei Chen   +9 more
doaj   +1 more source

Better, worse, or different than expected: on the role of value and identity prediction errors in fear memory reactivation

open access: yesScientific Reports, 2022
Although reconsolidation-based interventions constitute a promising new avenue to treating fear and anxieties disorders, the success of the intervention is not guaranteed.
A. M. V. Gerlicher   +2 more
doaj   +1 more source

Repeated labilization-reconsolidation processes strengthen declarative memory in humans. [PDF]

open access: yesPLoS ONE, 2011
The idea that memories are immutable after consolidation has been challenged. Several reports have shown that after the presentation of a specific reminder, reactivated old memories become labile and again susceptible to amnesic agents.
Cecilia Forcato   +2 more
doaj   +1 more source

Differential involvement of brain-derived neurotrophic factor in reconsolidation and consolidation of conditioned taste aversion memory. [PDF]

open access: yesPLoS ONE, 2012
Consolidated memory can re-enter states of transient instability following reactivation, which is referred to as reconsolidation, and the exact molecular mechanisms underlying this process remain unexplored. Brain-derived neurotrophic factor (BDNF) plays
Yue Wang   +6 more
doaj   +1 more source

Over the Edge: Extending the duration of a reconsolidation intervention for spider fear

open access: yesTranslational Psychiatry, 2022
Pharmacologically disrupting fear memory reconsolidation dramatically reduces fear behaviour. For example, 2–3 min of tarantula exposure followed by 40 mg of propranolol HCl (i.e., a reconsolidation intervention) abruptly decreased spider avoidance, an ...
Anna I. Filmer   +4 more
doaj   +1 more source

Memory reconsolidation in aversive and appetitive settings

open access: yesFrontiers in Behavioral Neuroscience, 2013
Memory reconsolidation has been observed across species and in a number of behavioural paradigms. The majority of memory reconsolidation studies have been carried out in pavlovian fear conditioning and other aversive memory settings, with potential ...
Amy Claire Reichelt   +2 more
doaj   +1 more source

Acid-sensing ion channel 1a regulates the specificity of reconsolidation of conditioned threat responses

open access: yesJCI Insight, 2022
Recent research on altering threat memory has focused on a reconsolidation window. During reconsolidation, threat memories are retrieved and become labile.
Erin E. Koffman   +10 more
doaj   +1 more source

Consolidation, reconsolidation, and extinction of contextual fear memory depend on de novo protein synthesis in the locus coeruleus

open access: yesBrain Research Bulletin, 2023
Memory consolidation is the process underlying the stabilization of labile short-term memory and the generation of long-term memory for persistent memory storage. The retrieval of contextual fear memory induces two distinct and opposite memory processes:
Yu Arihara, Yudai Fukuyama, Satoshi Kida
doaj   +1 more source

Consolidation/reconsolidation therapies for the prevention and treatment of PTSD and re-experiencing: a systematic review and meta-analysis

open access: yesTranslational Psychiatry, 2021
Translational research highlights the potential of novel 'memory consolidation/reconsolidation therapies' to treat re-experiencing symptoms and post-traumatic stress disorder (PTSD).
Laurence Astill Wright   +3 more
doaj   +1 more source

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