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The Amygdala, Fear, and Memory
Annals of the New York Academy of Sciences, 2003Abstract: Lesions of the frontotemporal region of the amygdala, which includes lateral and basal nuclei, cause a loss of conditional fear responses, such as freezing, even when the lesions are made over a year and a half from the original training. These amygdala‐damaged animals are not hyperactive and show normal reactivity to strong stimuli such as ...
Michael S, Fanselow, Greg D, Gale
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Selective Erasure of a Fear Memory
Science, 2009Memories are thought to be encoded by sparsely distributed groups of neurons. However, identifying the precise neurons supporting a given memory (the memory trace) has been a long-standing challenge. We have shown previously that lateral amygdala (LA) neurons with increased cyclic adenosine monophosphate response element–binding protein (CREB) are ...
Han, Jin-Hee +9 more
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Science, 2009
Why are memories of traumatic events nearly impossible to eliminate?
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Why are memories of traumatic events nearly impossible to eliminate?
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Reward memories extinguish fear
Nature Reviews Neuroscience, 2020Fear extinction memories are formed and stored within a population of reward-encoding neurons in the basolateral amygdala.
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Propranolol Decreases Fear Expression by Modulating Fear Memory Traces
Biological Psychiatry, 2021Posttraumatic stress disorder can develop after a traumatic event and results in heightened, inappropriate fear and anxiety. Although approximately 8% of the U.S. population is affected by posttraumatic stress disorder, only two drugs have been approved by the Food and Drug Administration to treat it, both with limited efficacy.
Sofia Leal Santos +8 more
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German Research, 2016
AbstractIt's a worrying fact that one in five people will experience an anxiety disorder at some point in their lives. This makes it all the more important to understand the cellular basis and molecular mechanisms of these emotions. Neurophysiology research is providing some illuminating answers.
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AbstractIt's a worrying fact that one in five people will experience an anxiety disorder at some point in their lives. This makes it all the more important to understand the cellular basis and molecular mechanisms of these emotions. Neurophysiology research is providing some illuminating answers.
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Switching tracks in fear memories
Science Translational Medicine, 2017The brain circuits underlying fear memories can be reorganized by updating old memories with new information.
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Science, 2004
The recall of a memory by a reminder stimulus places this memory back into an active and labile state, from which it is reconsolidated into an inactive and stable state. Is this cellular reconsolidation of memory simply a recapitulation of the events engaged at consolidation, or is there a more complicated process at work (see the ...
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The recall of a memory by a reminder stimulus places this memory back into an active and labile state, from which it is reconsolidated into an inactive and stable state. Is this cellular reconsolidation of memory simply a recapitulation of the events engaged at consolidation, or is there a more complicated process at work (see the ...
openaire +2 more sources