Results 71 to 80 of about 176,132,754 (255)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Scene in the play,"A Pageant of the Lower Cape Fear""

, 1921
Attendees watching actors in a scene of ""A Pageant of the Lower Cape Fear," a historical play performed at the Dudley Mansion on the Cape Fear in June 1921, written and produced by the Wilmington chapter of the North Carolina Sorosis Club.1920s (1920 ...

core   +6 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A qualitative study evaluating experiences of a lifestyle intervention in men with prostate cancer undergoing androgen suppression therapy [PDF]

, 2012
Background - The severe iatrogenic hypogonadal state induced by medical castration used for treatment of prostate cancer is associated with adverse effects including fatigue, increased fracture risk, and a decrease in skeletal muscle function, which ...
Saxton John M, Nanton Veronica, Helen Crank, Rosario, DJ, Sohanpal, R, Bourke, Liam, John M Saxton, Crank, H., Saxton, John, Bourke Liam, Crank, Helen, Liam Bourke, Saxton, J.M., Nanton, Veronica, Crank Helen, Rosario, D.J., Saxton, John M., Ratna Sohanpal, Sohanpal, Ratna, Saxton, JM, Nanton, V., Bourke, L, Nanton, V, Rosario, Derek J., Sohanpal Ratna, Rosario Derek J, Rosario, D, Derek J Rosario, Veronica Nanton, Crank, H, Bourke, L., Sohanpal, R.   +31 more
core   +2 more sources

Effectiveness of Acceptance and Commitment Therapy Management on Self-Differentiation and Fear of Disease Progression in Patients with Breast Cancer

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2020
BACKGROUND AND OBJECTIVE: Fear of disease progression and rejection of what happened and not being able to distinguish oneself from mental processes cause confusion in mental health.
M Hasannezhad Reskati, SH Hosseini, R Alizadeh-Navaei, S Khosravi, B Mirzaian   +4 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Prolonged survival of patients receiving trastuzumab beyond disease progression for HER2 overexpressing metastatic breast cancer (MBC) [PDF]

, 2005
Background: The aim of this retrospective analysis was to evaluate the impact of trastuzumab-based regimens on the survival of patients with HER2-overexpressing metastatic breast cancer (MBC).
Heinrich, B., Stemmler, H. J., Kahlert, S., Heinemann, Volker, Siekiera, W., Untch, M.   +5 more
core   +1 more source

Correlation between fear of disease progression and quality-of-life in non-dialysis patients with chronic kidney disease in stages 3-5

Linchuang shenzangbing zazhi
Objective To evaluate the influencing factors of fear of disease progression and examine its impact on quality-of-life in non-dialysis patients with chronic kidney disease （CKD） in stages 3-5.
Yun-fei Wang, Yu-yu Zhu, De-guang. Wang
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source