Results 81 to 90 of about 176,132,754 (255)

City of fear

, 2017
Urban problems have roots in much more abstract issues than only urban design. To understand this, we must cross the approaches of sociologists, politicians, historians, psychologists or criminologists, to name a few.
City of Fear
core  

Fear of disease progression and psychological factors in postoperative lung cancer patients

World Journal of Psychiatry
BACKGROUND Patients who undergo lung cancer surgery frequently experience a fear of disease progression (FoP), which can negatively affect their quality of life. Understanding the varying degrees of FoP and related psychological distress experienced by such patients is essential to develop effective interventions. Thus, in this study,
Min-Jie Chen, Wei Lei, Jun Zhou, Li-Xiu Chen, Tao Hui, Xi Lu   +5 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

fear of progression in patients with myocardial infarction, renal transplantation and Crohn´s disease

, 2014
Die Furcht vor dem Fortschreiten einer chronischen Erkrankung, die sog. Progredienzangst, stellt für Betroffene oft ein zentrales Problem dar, und zeigt, in Abhängigkeit von dem chronischen Grundleiden der Patienten in der Regel deutliche Unterschiede ...
Volmer, Sandra
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

[Fear of progression in parents of children with cancer: adaptation of the Fear of Progression Questionnaire and correlates].

, 2015
Fear of Progression (FoP), the fear of further disease progression, is one of the most common psychological strains of chronically ill patients and can also be found in healthy partners of cancer patients. Parents of children with cancer are also at risk
Schepper, F;Abel, K;Herschbach, P;Christiansen, H;Mehnert, A;Martini, J
core   +1 more source

Fear of Recurrence and Progression in People with Heart Disease: Risk Factors and Implications for Emotional Support

Behavioral Sciences
Support to manage fear of recurrence and progression (FoRP) is a major concern and a commonly unmet need for people with chronic illness. The current study identified profiles of and risk factors for FoRP in people with heart disease. A sample of 241 participants completed 44 cardiac-specific FoRP items and provided demographic, clinical, and ...
Sarah T. Clarke, Barbara M. Murphy, Robert Hester, Alun C. Jackson   +3 more
openaire   +3 more sources