Results 111 to 120 of about 792,979 (310)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Why Are Maximizers More Vulnerable to Fear of Missing Out? Exploring the Link Between Maximization and Fear of Missing Out Through Variety-Seeking

SAGE Open
There is a growing body of research on FoMO, yet the causal link between maximization and FoMO remains underexplored. This paper addresses this gap by investigating the mediating role of variety-seeking in the relationship between maximization and FoMO ...
Volkan Doğan, Enis Yakut, Selin Göral Nazlıoğlu, Ali Emre Aydın, Bahadır Ayar, Derya Yalçın Doğan   +5 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

FOMO (Fear Of Missing Out)

Italiano digitale, 2022
openaire   +2 more sources

Stranger Danger! [PDF]

, 2018
This article discusses the historical origins of the “stranger danger” myth, including the conditions that fueled the spread of panic. It explains how the myth was bolstered by increased media coverage, emotional appeals by parents, and public awareness ...
Wodda, Aimee
core   +1 more source

Parent\u2019s perception of children\u2019s fear: from FSSC-IT to FSSC-PP [PDF]

, 2015
Studies involving parents' reports about children's fears and multiple informant comparisons are less extended than investigations on children's self-reporting fear schedules.
Dazzi, Carla, Del Vecchio, E., DI RISO, Daniela, Mannarini, Stefania, Salcuni, Silvia   +4 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

PERAN FEAR OF MISSING OUT TERHADAP PERILAKU PHUBBING PADA USIA DEWASA AWAL [PDF]

Current technological developments have a huge impact on human life. This research focuses on the phenomenon of phubbing behavior in early adulthood, especially in emerging adulthood.
Habibulloh, Nauval
core  

Fear of Missing Out (FoMO): A Current Review

Psikiyatride Güncel Yaklaşımlar, 2021
Son zamanlarda, insanlar arası iletişim ve etkileşimin büyük çoğunluğunun internet ve mobil cihazlar aracılığıyla gerçekleştirilmesi ve yaygın sosyal medya kullanımı, insanlara belli avantajlar sağlamanın yanı sıra yeni olumsuzluklar da katmaktadır. Alan yazında Fear of Missing Out (FoMO) olarak adlandırılan, Türkçeye Gelişmeleri Kaçırma Korkusu (GKK ...
TANHAN, Fuat, ÖZOK, Halil İbrahim, TAYİZ, Volkan   +2 more
openaire   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source