Results 121 to 130 of about 805,309 (392)

Ordering CT pulmonary angiography to exclude pulmonary embolism: defense versus evidence in the emergency room [PDF]

, 2018
Purpose: To identify reasons for ordering computed tomography pulmonary angiography (CTPA), to identify the frequency of reasons for CTPA reflecting defensive behavior and evidence-based behavior, and to identify the impact of defensive medicine and of ...
Buatsi, Janet, Exadaktylos, Aristomenis, Kleim, Birgit, Rohacek, Martin, Stoupis, Christoforos, Szucs-Farkas, Zsolt, Zimmermann, Heinz   +6 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Examining experiential avoidance as a mediator of the relation between anxiety sensitivity and depressive symptoms [PDF]

, 2019
Initial evidence suggests that experiential avoidance (EA) mediates the relation between anxiety sensitivity (AS) and depression. We examined the AS-EA-depression pathway, examining both concurrent, and prospective (cross-lag), mediation models ...
Stein, Aliza Tova
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The relationship between personality type and fulfillment of basic needs with the FoMO Syndrome among adolescents in East Java

Healthcare in Low-resource Settings
Fear of Missing Out (FoMO) stems from individuals' dissatisfaction with their basic needs, and each individual develops distinct FoMO characteristics. This research aimed to analyze the relationship between personality types, fulfillment of basic needs ...
Dhian Satya Rachmawati, A.V. Sri Suhardiningsih, Sisi Istiyana Dewi, Rizky Dzariyani Laili   +3 more
doaj   +1 more source

HUBUNGAN REGULASI DIRI DENGAN FEAR OF MISSING OUT PADA PENGGUNA TIKTOK DEWASA AWAL [PDF]

Social media has become an important part of the daily lives of many individuals, especially among early adulthood. One of the popular social media platforms is TikTok. Majority TikTok users in Indonesia come from early adulthood, in age range from 18 to
Febriani, Mutia Indria
core  

Factors Influencing Adherence to Antiretroviral Treatment in Nepal: A Mixed-Methods Study [PDF]

, 2012
Background Antiretroviral therapy (ART) is a lifesaver for individual patients treated for Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS).
Freeman, Jennifer, Randall, Julian, Simkhada, Padam, van Teijlingen, Edwin, Wasti, Sharada Prasad   +4 more
core   +5 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Buffer or amplifier? Longitudinal effects of social support for functional autonomy/dependence on older adults’ chronic-pain experiences [PDF]

, 2017
Objective: This longitudinal study aimed to investigate (a) the moderating role of formal social support for functional autonomy versus dependence on the relationship between pain intensity and pain-related disability among older adults with chronic pain
Bernardes, Sónia F, Beyers, Wim, Goubert, Liesbet, Matos, Martha   +3 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source