Results 141 to 150 of about 805,309 (392)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Developing Children's Oral Health Assessment Toolkits Using Machine Learning Algorithm. [PDF]

open access: yes, 2020
ObjectivesEvaluating children's oral health status and treatment needs is challenging. We aim to build oral health assessment toolkits to predict Children's Oral Health Status Index (COHSI) score and referral for treatment needs (RFTN) of oral health ...
Coulter, ID   +10 more
core  

Fear of Missing Out (FoMO) and Recommendation Algorithms: Analyzing Their Impact on Repurchase Intentions in Online Marketplaces

open access: yesInternational Journal of Advanced Computer Science and Applications
—The rapid growth of e-commerce has intensified consumers' Fear of Missing Out (FoMO), influencing their repurchase intentions. This study aims to examine the impact of online FoMO on repurchase intentions in marketplaces, emphasizing the role of ...
Ati Mustikasari   +4 more
semanticscholar   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Prevalence of Internet addiction and its impact on the physiological balance of mental health

open access: yesNational Journal of Physiology, Pharmacy and Pharmacology, 2016
Background: Internet usage beyond normal limit becomes problematic, leading to various comorbidities. A new alarming disorder known as the FoMO (fear of missing out) has been identified as one such comorbidity.
Naren Vaidya   +2 more
doaj   +1 more source

Social media fear of missing out: psychometrics evaluation based on Indonesian evidence [PDF]

open access: diamond, 2018
S Syahniar   +7 more
openalex   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

PERAN FEAR OF MISSING OUT TERHADAP PERILAKU PHUBBING PADA USIA DEWASA AWAL [PDF]

open access: yes
Current technological developments have a huge impact on human life. This research focuses on the phenomenon of phubbing behavior in early adulthood, especially in emerging adulthood.
Habibulloh, Nauval
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

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