Results 111 to 120 of about 4,702,024 (340)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Clinical feasibility of a play-based assessment of motor speech disorders in young children in Austria

Frontiers in Communication
BackgroundThere is a lack of valid measures for the differential diagnosis of childhood apraxia of speech (CAS) worldwide, especially ones that are suitable for young children.
Gertraud Erlacher, Gertraud Erlacher, Shelley L. Velleman, Daniel Holzinger, Daniel Holzinger   +4 more
doaj   +1 more source

MoonLITE – Technological feasibility of the penetrator concept [PDF]

, 2008
Introduction: While the surface missions to the Moon of the 1960s and 1970s achieved a great deal, scientifically a great deal was also left unresolved. The recent plethora of lunar missions (flown or proposed) reflects resurgence in interest in the Moon,
Smith, A., Crawford, I. A., Ball, A. J., Barber, S. J., Church, P., Gao, Y., Gowen, R. A., Griffiths, A., Hagermann, A., Pike, W. T., Phipps, A., Sheridan, S., Sims, M. R., Talboys, D. L., Wells, N.   +14 more
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Evaluating the Impact of Needle-Free Delivery of Inactivated Polio Vaccine on Nigeria’s Routine Immunization Program: An Implementation Hybrid Trial

Vaccines
Background/Objectives: The Tropis® ID device (PharmaJet®), a needle-free injection system, is a World Health Organization prequalified, hand-held device, which delivers intradermal injections without the use of needles and has previously been used for ...
Diwakar Mohan, Mercy Mvundura, Sidney Sampson, Victor Abiola Adepoju, Garba Bello Bakunawa, Chidinma Umebido, Adachi Ekeh, Joe Little, Catherine Daly, Christopher Morgan, Sunday Atobatele, Paul LaBarre, Elizabeth Oliveras   +12 more
doaj   +1 more source

Fire Island Feasibility Study: Summary Report — Final Report [PDF]

, 1986
This report is part of the Fire Island Prison Feasibility Study, a project conducted jointly by the School of Justice and School of Engineering at University of Alaska, Anchorage under contract to the Alaska Department of Corrections.
UAA School of Engineering, UAA School of Justice   +1 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Patient and provider preferences for long-acting TB preventive therapy

IJTLD Open
BACKGROUND: Tuberculosis preventive therapy (TPT) is critical for TB elimination but is underutilised. Long-acting (LA) TPT can potentially improve linkage to care, treatment adherence and outcomes.
M. Vermeulen, K.K. Scarsi, R. Furl, H. Sayles, M.J. Anderson, S. Valawalkar, A. Kadam, S.R. Cox, V. Mave, M. Barthwal, C. Schutz, A. Ward, J. Dountio Ofimboudem, G. Meintjes, S. Rannard, A. Owen, S. Swindells, on behalf of the LONGEVITY consortium   +17 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

A virtual reality-based self-guided training on identification of negative automatic thoughts in healthy adults: a mixed-methods feasibility study

Frontiers in Psychiatry
BackgroundCognitive restructuring (CR) is an evidence-based psychological technique for depression. However, face-to-face CR is not easily accessible. Digital CR interventions often overlook the difficulties individuals experiencing depression encounter ...
Bixi Yang, Chenxi Liao, Yuqing Yang, Yuqing Yang, Binbin Shi, Caidi Zhang, Chunbo Li, Chunbo Li, Chunbo Li   +8 more
doaj   +1 more source