Results 41 to 50 of about 2,954,255 (299)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

From batch to continuous extractive distillation using thermodynamic insight: class 1.0-2 case B [PDF]

, 2011
A systematic feasibility analysis is presented for the separation azeotropic mixtures by batch and continuous extractive distillation. Based on batch feasibility knowledge, batch and continuous separation feasibility is studied under reflux ratio and ...
Benyounes, Hassiba, Gerbaud, Vincent, Shen, Weifeng   +2 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

PCM-Based heat exchanger for Low-Temperature hybrid residential air conditioning with ground-source heat pumps: Design and validation

Results in Engineering
This work presents the design, experimental validation, and performance evaluation of a patented phase change material–based thermal energy storage (PCM-TES) heat exchanger integrated into a hybrid open-loop ground-source heat pump (GSHP) system for low ...
J.M. García-Alonso, D. González-Peña, M. García-Fuente, C. Alonso-Tristán   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Lessons learned from conceptualising and operationalising the National Adolescent Health Programme or Rashtriya Kishor Swasthya Karyakram’s Learning Districts Initiative in six districts of India

Sexual and Reproductive Health Matters, 2023
In 2018, WHO with the support of the Ministry of Health and Family Welfare, India and partner organisations launched a Learning Districts Initiative to strengthen the district-level application of the National Adolescent Health Programme and to draw out ...
Alka Barua, Venkatraman Chandra-Mouli, Rajesh Mehta, Swati Shinde, Priyanka Garg, Qazi Najam, Aparajita Gogoi, Mohammed Ziauddin, Priyanka Kochar, Mini Kurup, Nilesh Patil, Amita Dhanu   +11 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Development of a single market for research services in the Eurasian Economic Union

Ekonomika Nauki, 2019
Based on the analysis of existing regulatory legal acts in the field of regulating the research activities of the member countries of the Eurasian Economic Union (EAEU), a conclusion was made about their similarity and the possibility of starting the ...
V. N. Kuzmin, E. A. Ilyukhina, L. G. Voronetskaya, S. V. Meloyan   +3 more
doaj   +1 more source

Construction of power flow feasibility sets [PDF]

, 2015
We develop a new approach for construction of convex analytically simple regions where the AC power flow equations are guaranteed to have a feasible solutions.
Dvijotham, Krishnamurthy, Turitsyn, Konstantin   +1 more
core  

Hortibot: Feasibility study of a plant nursing robot performing weeding operations – part IV [PDF]

, 2007
Based on the development of a robotic tool carrier (Hortibot) equipped with weeding tools, a feasibility study was carried out to evaluate the viability of this innovative technology. The feasibility was demonstrated through a targeted evaluation adapted
Jensen, Kjeld, Jensen, Lars Aa., Jørgensen, Rasmus N., Maagaard, Jørgen, Nørremark, Michael, Sørensen, Claus G.   +5 more
core   +1 more source