Results 121 to 130 of about 708,034 (258)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Evaluating the effectiveness of a transdiagnostic universal prevention program for both internalizing and externalizing problems in children: two feasibility studies. [PDF]

Child Adolesc Psychiatry Ment Health, 2022
Kishida K, Hida N, Ishikawa SI.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

How to optimise the use of innovative invasive devices: considerations for feasibility studies. [PDF]

Pilot Feasibility Stud
Hotton E, Wade J, Elliott D, Lenguerrand E, Crofts J, Blencowe N.   +5 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Transparency of informed consent in pilot and feasibility studies is inadequate: a single-center quality assurance study. [PDF]

Pilot Feasibility Stud, 2021
Khan MIU, Mbuagbaw L, Holek M, Bdair F, Durrani ZH, Mellor K, Eddy S, Eldridge SM, Chan CL, Campbell MJ, Bond CM, Hopewell S, Lancaster GA, Thabane L.   +13 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Diagnostic accuracy, fairness and clinical implementation of AI for breast cancer screening: results of multicenter retrospective and prospective technical feasibility studies. [PDF]

Nat Cancer
Kelly CJ, Wilson M, Warren LM, Sidebottom R, Halling-Brown M, Yang L, Morigami M, Venton J, Chopra R, Chang J, Dixon J, Gilbert FJ, Golden DI, Gruzewska E, Honeyfield L, Hujan A, Khodabakhshi D, Lewis E, Malhotra N, Mallya R, Ogunleye D, Purdy C, Sayres R, Sieniek M, Stoycheva T, Sy A, Thomas S, Ward D, Xi L, Xu S, Shetty S, Darzi A, Young K, Purushothaman H, Khoo L, Reddy M, Ashrafian H, Cunningham D.   +37 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Sample size justification in feasibility studies: moving beyond published guidance. [PDF]

Pilot Feasibility Stud
Montgomery R.
europepmc   +1 more source