Results 101 to 110 of about 708,034 (258)

Applying mixed methods to pilot feasibility studies to inform intervention trials. [PDF]

Pilot Feasibility Stud, 2022
Aschbrenner KA, Kruse G, Gallo JJ, Plano Clark VL.   +3 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Prescriptions for Connection—Social Prescribing for Older People in Australia: Protocol for a Feasibility Study

Health Expectations
Background Older people are living longer with unmet social needs that impact their health and wellbeing. Social prescribing programs connect individuals with nonclinical services to address these needs.
Heather Block, Candice Oster, Suzanne Dawson, Claire Gough, Gregory B. Crawford, Adelaide Boylan, Jan Angelo, Matthew Freeman, Rachel Milte, Helen Exley, Stacey George   +10 more
doaj   +1 more source

Feasibility Studies of Charge Exchange Measurements in pp Collisions at the LHC. [PDF]

Entropy (Basel), 2022
Fehérkuti A, Veres GI, Ulrich R, Pierog T.   +3 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Identification of different types of tumors based on photoacoustic spectral analysis: preclinical feasibility studies on skin tumors. [PDF]

J Biomed Opt, 2023
Zhang M, Wen L, Zhou C, Pan J, Wu S, Wang P, Zhang H, Chen P, Chen Q, Wang X, Cheng Q.   +10 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Feasibility studies of multimodal nonlinear endoscopy using multicore fiber bundles for remote scanning from tissue sections to bulk organs. [PDF]

Sci Rep, 2023
Bae H, Rodewald M, Meyer-Zedler T, Bocklitz TW, Matz G, Messerschmidt B, Press AT, Bauer M, Guntinas-Lichius O, Stallmach A, Schmitt M, Popp J.   +11 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Feasibility Studies of Nebulized SARS-CoV-2 Neutralizing Antibody in Mice and Cynomolgus Monkeys. [PDF]

Pharm Res, 2022
Jia J, Yin Z, Zhang X, Li H, Meng D, Liu Q, Wang H, Han M, Suo S, Liu Y, Hu P, Sun C, Li J, Xie L.   +13 more
europepmc   +1 more source