Results 101 to 110 of about 806,359 (300)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The feasibility of risk-stratified screening as routine practice in the NHS Breast Screening Programme in England: the PROCAS2 research programme

Programme Grants for Applied Research
Background Screening for breast cancer produces benefits through cancers being detected earlier, thereby reducing premature deaths and the need for more intensive treatment.
David P French, Lorna McWilliams, Katherine Payne, Victoria G Woof, Fiona Harrison, Andrew Jerrison, Matthew Machin, Stuart J Wright, Anthony Howell, Sacha J Howell, Louise S Gorman, Helen Ruane, Fiona Ulph, Nadeem Qureshi, Rachel Hawkins, Susan Astley, Anthony J Maxwell, Gillian Hutchison, Richard Dobrashian, Sarah Bowers, Paula Stavrinos, Sarah Sampson, Jake Southworth, Emma Thorpe, Michelle Harvie, Elaine F Harkness, Lynne Fox, Adam R Brentnall, Jack Cuzick, Stephen W Duffy, D Gareth Evans   +30 more
doaj   +1 more source

Psychometrics of patient-reported outcomes measurement information system in von Willebrand disease, inherited platelet function disorders, and rare bleeding disorders

Research and Practice in Thrombosis and Haemostasis
Background: Patient-reported outcomes measurement information system (PROMIS) measures can be used to measure patient-reported outcomes. PROMIS measures, including computer adaptive tests (CATs) and short forms, have demonstrated the ability to ...
Evelien S. van Hoorn, Sterre P.E. Willems, Wala Al Arashi, Annick S. de Moor, Calvin B. van Kwawegen, Lorynn Teela, Martijn A.H. Oude Voshaar, Idske C.L. Kremer Hovinga, Roger E.G. Schutgens, Saskia E.M. Schols, Frank W.G. Leebeek, Lotte Haverman, Marjon H. Cnossen, Samantha C. Gouw, Hester F. Lingsma, Marjolein Peters, Michiel Coppens, Marieke J.H.A. Kruip, Lize F.D. van Vulpen, Tessa C.M. van Gastel   +19 more
doaj   +1 more source

Evaluating the Utility of Mini-CEX as a Formative Assessment Tool for Paediatric Postgraduate Education: A Mixed-method Educational Interventional Study from Gujarat, India [PDF]

Journal of Clinical and Diagnostic Research
Introduction: The Mini Clinical Evaluation Exercise (mini-CEX) assesses doctor-patient interactions and clinical skills. Its use in Indian Postgraduate (PG) programmes is limited despite its effectiveness. Aim: To evaluate the utility of the mini-CEX as
Hemal Dave
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Intensive smoking cessation intervention in a nature-based setting: a feasibility study of the Danish gold standard program

Frontiers in Public Health
The implementation of nature-based interventions has demonstrated a positive impact on health outcomes and overall wellbeing. The knowledge of nature-based smoking cessation interventions is sparse but might offer potential benefits for smokers ...
Mie Sylow Liljendahl, Sanne Staal, Hanne Tønnesen   +2 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Promoting hEalthy Diet and Active Lifestyle (PEDAL): A protocol for the development and feasibility study of a multicomponent intervention among primary school children in Singapore

The open access publication is available at: https://doi.org/10.1186/s40814-024-01479-3Background Setting healthy lifestyle habits during the formative years of childhood is critical as habits can track to adulthood and help prevent obesity and chronic ...
Hildon, Zoe Jane-Lara, Chia, Michael, Chan, Cindy Mei Jun, Chia, Michael Yong Hwa, Muller-Riemenschneider, Falk, Chong, Mary Foong-Fong   +5 more
core   +1 more source

Evaluating the feasibility of "Friends in Nature," a complex nature-based social intervention to address loneliness and quality of life in six cities worldwide [PDF]

Background: Loneliness, a major public health concern, could be alleviated through social interventions with nature contact as a primary component. "Friends in Nature" is a complex nature-based social intervention designed to be implemented as part of ...
Litt, J.S., Blancafort Alias, Sergi, Jansson, Anu Helena, Vert, C., Masó-Aguado, M., Sachs, A., Garcia, G., Rautiainen, L.J., Roqué i Figuls, Marta, Bártová, A., Coll-Planas, L., Cattaneo, L., Pitkälä, K.H., Holmerová, I., Briones-Buixassa, L., Gascon, M., Carbó, A., Opacin, N., Universitat Autònoma de Barcelona, Domènech, Sara, Hidalgo, L.   +20 more
core   +1 more source