Results 91 to 100 of about 806,359 (300)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Medical management and intervention (using neurosurgical resection or stereotactic radiosurgery) versus medical management alone for symptomatic brain cavernoma: the CARE pilot RCT

Health Technology Assessment
Background The top priority for research into symptomatic cerebral cavernous malformation (also known as brain cavernoma) is whether to have medical management and intervention (using neurosurgical resection or stereotactic radiosurgery) or medical ...
Rustam Al-Shahi Salman, Neil Kitchen, Laura Forsyth, Vijeya Ganesan, Peter S Hall, Kirsty Harkness, Peter JA Hutchinson, Steff C Lewis, Matthias WR Radatz, Carole Turner, Julia Wade, David CS White, Philip M White   +12 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Development of a comprehensive clinical assessment protocol for low back and hip pain in powerlifters : a feasibility study

Background Low back and hip pain problems are frequent in powerlifting. There is a lack of information on the specific pain phenotypes and specific impairments in body function associated with these pain problems, as well as how to reach a clinical ...
Olofsson, Patrik, Aasa, Ulrika,, Olofsson, Patrik,, Aasa, Ulrika, Berglund, Lars,, Berglund, Lars   +5 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Acceptance and Commitment Therapy for people living with motor neuron disease: the COMMEND feasibility study and randomised controlled trial

Health Technology Assessment
Background Motor neuron disease is a progressive, fatal neurodegenerative disease for which there is no cure. Formal psychological therapies are not routinely part of United Kingdom standard motor neuron disease care due to a lack of evidence-based ...
Rebecca L Gould, Benjamin J Thompson, Charlotte V Rawlinson, Matt Bursnall, Mike Bradburn, Anju D Keetharuth, Tracey Young, Vanessa Lawrence, David A White, Robert J Howard, Marc A Serfaty, Lance M McCracken, Christopher D Graham, Ammar Al-Chalabi, Laura H Goldstein, Dynameni Androulaki-Koraki, Pavithra Kumar, Kirsty Weeks, Rebecca Gossage-Worrall, Emily J Turton, Simon Waterhouse, Nicola Drewry, Cindy Cooper, Pamela J Shaw, Christopher J McDermott   +24 more
doaj   +1 more source

Feasibility study questions [PDF]

British Journal of Anaesthesia, 2016
K L, Railton, S, Anwar
openaire   +2 more sources

What is a pilot or feasibility study? A review of current practice and editorial policy [PDF]

, 2010
Background: In 2004, a review of pilot studies published in seven major medical journals during 2000-01 recommended that the statistical analysis of such studies should be either mainly descriptive or focus on sample size estimation, while results from ...
Lancaster, Gillian, Lancaster Gillian A, Campbell Michael J, Campbell, M.J., Lancaster, G.A., Arain, Mubashir, Mubashir Arain, Arain Mubashir, Cindy L Cooper, Campbell, Michael J, Cooper Cindy L, Arain, M., Cooper, Cindy L, Gillian A Lancaster, Michael J Campbell, Cooper, C.L.   +15 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Using Physiological Markers to Assess Comfort during Neuromuscular Electrical Stimulation Induced Muscle Contraction in a Virtually Guided Environment: Pilot Study for a Path toward Combating ICU-Acquired Weakness

Sensors
We assessed the feasibility of implementing a virtually guided Neuromuscular Electrical Stimulation (NMES) protocol over the tibialis anterior (TA) muscle while collecting heart rate (HR), Numeric Pain Rating Scale (NPRS), and quality of contraction (QoC)
Ahmad Abou-Hamde, Lauren Philippi, Eric Jones, Christian Martin, Kingsley Wu, Michael Kundell, Sunita Mathur, Alireza Sadeghian, Maryam Davoudpour, Jane Batt, Adriana Ieraci, Sharon Gabison   +11 more
doaj   +1 more source