Results 81 to 90 of about 708,034 (258)

Erratum to: BMC Palliative Care, Vol. 17

BMC Palliative Care, 2017
Pilot and Feasibility Studies
doaj   +1 more source

Optimising cardiac surgery outcomes in people with diabetes: the OCTOPuS pilot feasibility study

Health Technology Assessment
Background Surgical outcomes are worse in people with diabetes, in part, because of the effects of hyperglycaemia, obesity and other comorbidities. Two important uncertainties in the management of people with diabetes undergoing major surgery exist: (1 ...
Richard IG Holt, Katharine Barnard-Kelly, Mayank Patel, Philip Newland-Jones, Suvitesh Luthra, Jo Picot, Helen Partridge, Andrew Cook   +7 more
doaj   +1 more source

Pilot and feasibility studies: extending the conceptual framework. [PDF]

Pilot Feasibility Stud, 2023
Bond C, Lancaster GA, Campbell M, Chan C, Eddy S, Hopewell S, Mellor K, Thabane L, Eldridge S.   +8 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Feasibility and constraints of Bragg peak FLASH proton therapy treatment planning

Frontiers in Oncology
IntroductionFLASH proton therapy (FLASH-PT) requires ultra-high dose rate (≥ 40 Gy/s) protons to be delivered in a short timescale whilst conforming to a patient-specific target. This study investigates the feasibility and constraints of Bragg peak FLASH-
Nathalie Lövgren, Ingrid Fagerström Kristensen, Ingrid Fagerström Kristensen, Kristoffer Petersson, Kristoffer Petersson   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Doppler ultrasound surveillance of recently formed haemodialysis arteriovenous fistula: the SONAR observational cohort study

Health Technology Assessment
Background Arteriovenous fistulas are considered the best option for haemodialysis provision, but as many as 30% fail to mature or suffer early failure. Objective To assess the feasibility of performing a randomised controlled trial that examines whether,
James Richards, Dominic Summers, Anna Sidders, Elisa Allen, Mohammed Ayaz Hossain, Subhankar Paul, Matthew Slater, Matthew Bartlett, Regin Lagaac, Emma Laing, Valerie Hopkins, Chloe Fitzpatrick-Creamer, Cara Hudson, Joseph Parsons, Samuel Turner, Andrew Tambyraja, Subash Somalanka, James Hunter, Sam Dutta, Neil Hoye, Sarah Lawman, Tracey Salter, Mohammed Farid Aslam, Atul Bagul, Rajesh Sivaprakasam, George E Smith, Helen L Thomas, Zia Moinuddin, Simon R Knight, Nicholas Barnett, Reza Motallebzadeh, Gavin J Pettigrew   +31 more
doaj   +1 more source

Feasibility and clinical integration study on low⁃cost digital gait analysis system based on dual Kinect V2

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To develop a low⁃cost digit⁃intelligent gait analysis system based on dual Kinect V2 sensors and universal open⁃source software platforms (DKS), and to evaluate its feasibility and accuracy for gait analysis. Methods A total of 15 patients with
ZHANG Shi⁃yu, CHEN Guo⁃rong, MAIMAITIABULA Saimaiti, XU Xing⁃hua, ZHUANG Jia⁃shu, CHEN Xiao⁃lei   +5 more
doaj   +1 more source

How do pilot and feasibility studies inform randomised placebo-controlled trials in surgery? A systematic review. [PDF]

BMJ Open, 2023
Cousins S, Gormley A, Chalmers K, Campbell MK, Beard DJ, Blencowe NS, Blazeby JM.   +6 more
europepmc   +1 more source