Results 81 to 90 of about 806,359 (300)

Transdiagnostic group cognitive behaviour therapy for anxiety in bipolar disorder : a pilot feasibility and acceptability study [PDF]

, 2020
Objective: Anxiety is prominent for many people living with bipolar disorder, yet the benefit of psychological interventions in treating this co-morbidity has been minimally explored and few studies have been conducted in a group format. This study aimed
Meade, Tanya (R11400), Perich, Tania (R18286), Mitchell, Philip B.   +2 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Feasibility, acceptability, and outcome responsiveness of the SYMPERHEART intervention to support symptom perception in persons with heart failure and their informal caregivers: a feasibility quasi-experimental study

, 2023
Background Symptom perception is an important process of heart failure (HF) self-care that persons with HF need in order to master self-care management. It also leads to better patient outcomes.
Wicht, J., Schäfer‑Keller, Petra, Maria Liljeroos, Wicht, Justine,, Santos, G.C., Kris Denhaerynck, Jurgens, Corrine Y., Roger Hullin, Tschann, Kelly,, Liljeroos, M., Jurgens, Corrine Y.,, Petra Schäfer-Keller, Hullin, Roger,, Schaefer-Keller, Petra, Denhaerynck, K., Tschann, K., Schaefer-Keller, Petra,, Justine Wicht, Wicht, Justine, Kelly Tschann, Santos, Gabrielle Cécile, Jurgens, C.Y., Hullin, Roger, Liljeroos, Maria,, Tschann, Kelly, Liljeroos, Maria, Santos, Gabrielle Cecile,, Gabrielle Cécile Santos, Denhaerynck, Kris, Denhaerynck, Kris,, Corrine Y. Jurgens, Schäfer-Keller, P., Hullin, R.   +32 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Applying a co-designed medication plan for safer medication treatment in older persons : a feasibility study

BackgroundTo promote patient safety, international guidelines highlight the importance of a joint plan for continued treatment in older persons. Accordingly, in a co-design initiative involving older persons and healthcare professionals, a medication ...
Johansson, Linda,, Holmqvist, Malin,, Thor, Johan,, Ros, Axel,   +3 more
core   +1 more source

Feasibility and usefulness of a leadership intervention to implement evidence-based falls prevention practices in residential care in Canada

, 2019
Background: Leadership is critical to supporting and facilitating the implementation of evidence-based practices in health care. Yet, little is known about how to develop leadership capacity for this purpose. The aims of this study were to explore the (1)
Graham, Ian D., Graham, Ian D.,, Eldh, Ann Catrine, Fiset, Val,, Eldh, Ann C, Gifford, Wendy,, Graham, Ian D, Graham, I. D., Abdul-Fatah, Tara, Wallin, Lars,, Åberg, Anna Cristina,, Thavorn, Kednapa, Fiset, Val, Thavorn, K., Fiset, V, Graham, ID, Lewis, Krystina B.,, Fiset, V., Gifford, W, Eldh, AC, Eldh, Ann Catrine,, Lewis, Krystina B., Thavorn, K, Gifford, W., Lewis, KB, Wallin, L,, Åberg, Anna Cristina, Eldh, A. C., Abdul-Fatah, T., Aberg, Anna C, Gifford, Wendy, Lewis, Krystina B, Lewis, K. B., Aberg, A. C., Thavorn, Kednapa,, Abdul-Fatah, Tara,, Abdul-Fatah, T, Aberg, AC, Wallin, Lars   +38 more
core   +1 more source

Internet-based cognitive behavior therapy for problem gambling in routine care : protocol for a non-randomized pilot and feasibility trial

, 2020
Background Problem gambling and gambling disorder are major public health concerns worldwide, and awareness of associated negative consequences is rising.
Berman, Anne H.,, Molander, Olof, Berman, AH, Carlbring, Per, Carlbring, Per,, Bjureberg, Johan, Ramnerö, Jonas,, Molander, O,, Ramnerö, Jonas, Bjureberg, J,, Lindner, Philip, Berman, Anne H., Ramnero, J, Lindner, Philip,, Molander, Olof,, Lindner, P,, Bjureberg, Johan,, Carlbring, P   +17 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The evaluation of a brief ICBT program with therapist support for individuals with gambling problems in the context of a gambling helpline: a randomized pilot trial

, 2023
Background and aims Gambling helplines are a natural way of first contact for individuals with gambling problems. However, few studies have evaluated the feasibility and effectiveness of brief interventions in a gambling helpline.
Hellner, Clara,, Magnusson, Kristoffer, Magnusson, Kristoffer,, Andersson, Gerhard, Wall, Hakan,, Rosendahl, Ingvar, Hellner, C,, Jayaram-Lindstrom, N, Hellner, Clara, Wall, H,, Andersson, Gerhard,, Wall, Hakan, Jayaram-Lindstrom, Nitya,, Rosendahl, I,, Rosendahl, Ingvar,, Magnusson, K,, Jayaram-Lindstrom, Nitya, Andersson, G,   +17 more
core   +1 more source