Results 71 to 80 of about 806,359 (300)

Defining feasibility and pilot studies in preparation for randomised controlled trials: development of a conceptual framework [PDF]

, 2016
We describe a framework for defining pilot and feasibility studies focusing on studies conducted in preparation for a randomised controlled trial.

core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Geriatric Assessment in CKD Care: An Implementation Study

Kidney Medicine
Rationale & Objective: Older people with progressive chronic kidney disease (CKD) have complex health care needs. Geriatric evaluation preceding decision making for kidney replacement is recommended in guidelines, but implementation is lacking in ...
Carlijn G.N. Voorend, Noeleen C. Berkhout-Byrne, Leti van Bodegom-Vos, Adry Diepenbroek, Casper F.M. Franssen, Hanneke Joosten, Simon P. Mooijaart, Willem Jan W. Bos, Marjolijn van Buren, Arjan van Alphen, Noeleen Berkhout-Byrne, Fenna van Breda, Marjolijn van Buren, Henk Boom, Willem Jan Bos, Adry Diepenbroek, Marielle Emmelot-Vonk, Casper Franssen, Carlo Gaillard, Nel Groeneweg-Peeters, Bettie Hoekstra, Nienke Hommes, Francoise Hoornaar, Hanneke Joosten, Joep Lagro, Elisabeth Litjens, Femke Molenaar, Simon Mooijaart, Aegida Neradova, Mike Peters, Michelle Troost, Wilma Veldman, Carlijn Voorend, Lidwien Westerbos, Carlijne Westerman-van der Wijden, Judith Wierdsma   +35 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Feasibility Study

COBE Business Review, 2019
This feasibility study evaluates the viability of JAKIV Company, a start-up partnership planning to produce and market Ecoalily, an all-natural, eco-friendly facial scrub made from locally sourced ingredients including waterlily charcoal, aloe vera, honey, lemongrass extract, rosemary oil, vitamin E, and grapefruit seed extract.
Josiah Natividad, Aira Summer Andres, Kevin James Agcaoili, Irene Emee Gaspar, Vera Shaina Acacio   +4 more
  +4 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A Dengue Vaccine: Will It be Accepted and Is It Feasible? Lessons from Barranquilla, Colombia, and Merida, Venezuela

Microorganisms, 2019
With one vaccine on the market and others in clinical trials, policy makers in dengue endemic regions face the decision of whether to introduce a dengue vaccine in their communities.
Elizabeth McMahon, Liliana Encinales, Carlos Navarro Encinales, Silvana Vielma, Nelly Pacheco, Lil Geraldine Avendaño Echavez, Sandra Acosta Rodríguez, Milena Calderon, Silvia Encinales Sanabria, Lorena Encinales Sanabria, Ericka Serrano Bernal, Andrés Gonzaléz Coba, Dennys Jiménez, Gary Simon, Aileen Y. Chang   +14 more
doaj   +1 more source

Correlation between self-efficacy, fear of movement, empowerment, enablement, and number of visits to physiotherapist among patients with musculoskeletal disorders in primary health care [Elektronisk resurs] : a feasibility study

, 2022
Background: Musculoskeletal disorders are a costly burden for health care and social care services. Patients with musculoskeletal disorders are often treated by physiotherapists in primary health care. Psychosocial variables can be a significant obstacle
Törnblom, Madelene,, Hansson, Eva Ekvall,, Lund University.   +2 more
core   +1 more source