Results 71 to 80 of about 1,660,759 (289)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Utilizing FEM-Software to quantify pre- and post-interventional cardiac reconstruction data based on modelling data sets from surgical ventricular repair therapy (SVRT) and cardiac resynchronisation therapy (CRT)

BioMedical Engineering OnLine, 2006
Background Left ventricle (LV) 3D structural data can be easily obtained using standard transesophageal echocardiography (TEE) devices but quantitative pre- and intraoperative volumetry and geometry analysis of the LV is presently not feasible in the ...
Verhey Janko F, Nathan Nadia S
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Strategy to prime the host and cells to augment therapeutic efficacy of progenitor cells for patients with myocardial infarction

Frontiers in Cardiovascular Medicine, 2016
Cell therapy in myocardial infarction (MI) is an innovative strategy that is regarded as a rescue therapy to repair the damaged myocardium and to promote neovascularization for the ischemic border zone.
Jeehoon Kang, Jeehoon Kang, Tae-Won Kim, Tae-Won Kim, Jin Hur, Hyo-Soo Kim, Hyo-Soo Kim, Hyo-Soo Kim   +7 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Spectral decompositions and feasible directions in the axial three-index assigment problem

, 2000
In this paper, we give some results on the spectral decomposition and generalized inverse of the matrix A which is the coefficient matrix of the axial three-index assignment problem and investigate relations between eigenvalues and eigenvectors of the ...
Y. Çeven
core   +1 more source

Optimality Conditions for Approximate Solutions in Multiobjective Optimization Problems

Journal of Inequalities and Applications, 2010
We study first- and second-order necessary and sufficient optimality conditions for approximate (weakly, properly) efficient solutions of multiobjective optimization problems. Here, tangent cone, -normal cone, cones of feasible directions, second-order
Lee HeungWingJoseph, Gao Ying, Yang Xinmin   +2 more
doaj  

Sliced Online Model Checking for Optimizing the Beam Scheduling Problem in Robotic Radiation Therapy

Electronic Proceedings in Theoretical Computer Science
In robotic radiation therapy, high-energy photon beams from different directions are directed at a target within the patient. Target motion can be tracked by robotic ultrasound and then compensated by synchronous beam motion.
Beckers, Lars, Gerlach, Stefan, Lübke, Ole, Schlaefer, Alexander, Schupp, Sibylle   +4 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Nonlinear goal programming model application in optimal economy development policy choosing

Economic Analysis, 2019
In this paper a new nonlinear goal programming model (NGP) and a new interactive goal programming methodology (MINGP) have been developed which are more applicable then existent.
Lazo Roljić, Muris Dujsić
doaj   +2 more sources