Results 71 to 80 of about 809,365 (289)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Strategy to prime the host and cells to augment therapeutic efficacy of progenitor cells for patients with myocardial infarction

Frontiers in Cardiovascular Medicine, 2016
Cell therapy in myocardial infarction (MI) is an innovative strategy that is regarded as a rescue therapy to repair the damaged myocardium and to promote neovascularization for the ischemic border zone.
Jeehoon Kang, Jeehoon Kang, Tae-Won Kim, Tae-Won Kim, Jin Hur, Hyo-Soo Kim, Hyo-Soo Kim, Hyo-Soo Kim   +7 more
doaj   +1 more source

Quantum limit in a quasi-one-dimensional conductor in a high tilted magnetic field

, 2017
Recently, we have suggested Fermi-liquid - non-Fermi-liquid angular crossovers which may exist in quasi-one-dimensional (Q1D)conductors in high tilted magnetic fields [see A.G. Lebed, Phys. Rev. Lett.
Lebed, Andrei G.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

An expressive hybrid model for the composition of cardinal directions [PDF]

, 2003
In our previous paper (Kor and Bennett, 2003), we have shown how the nine tiles in the projection-based model for cardinal directions can be partitioned into sets based on horizontal and vertical constraints (called Horizontal and Vertical Constraints ...
Bennett, B, Kor, A
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Research progress on the pathogenesis, prevention and treatment of immune platelet transfusion refractoriness

Zhongguo shuxue zazhi
Platelet transfusion refractoriness (PTR) is one of the common problems in platelet transfusion, significantly impacting patient clinical outcomes and increasing the demand for allogeneic platelet transfusion.
LI Penghui, WU Chenggao, LE Aiping
doaj   +1 more source

A study of purely astrometric selection of extragalactic point sources with Gaia

, 2015
Selection of extragalactic point sources, e.g. QSOs, is often hampered by significant selection effects causing existing samples to have rather complex selection functions. We explore whether a purely astrometric selection of extragalactic point sources,
Fynbo, Johan P. U., Heintz, Kasper E., Høg, Erik   +2 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Sub‐slab anisotropy beneath the Sumatra and circum‐Pacific subduction zones from source‐side shear wave splitting observations

Geochemistry, Geophysics, Geosystems, 2014
Understanding the dynamics of subduction is critical to our overall understanding of plate tectonics and the solid Earth system. Observations of seismic anisotropy can yield constraints on deformation patterns in the mantle surrounding subducting slabs ...
Colton Lynner, Maureen D. Long
doaj   +1 more source