Results 91 to 100 of about 809,365 (289)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Radiation OncologyObjective To evaluate the impact of the residual setup errors from differently shaped region of interest (ROI) and investigate if surface-guided setup can be used in radiotherapy with concurrent tumor treating fields (TTFields) for glioblastoma.
Jiajun Zheng +8 more
doaj +1 more source
Box-constrained vector optimization: a steepest descent method without “a priori” scalarization [PDF]
In this paper a notion of descent direction for a vector function defined on a box is introduced. This concept is based on an appropriate convex combination of the “projected” gradients of the components of the objective functions.
Miglierina Enrico +2 more
core
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
Survey on trusted cloud platform technology
Tongxin xuebao, 2019 Information security technology confronts severe challenges because of the safety demands of cloud computing.The trustworthiness and self-safety of cloud computing platform are the foundation of cloud computing security.The confidence of cloud users is ...
Xinfeng HE, Junfeng TIAN, Fanming LIU
doaj +2 more sources
Separating Rigid Motion for Continuous Shape Evolution
ELCVIA Electronic Letters on Computer Vision and Image Analysis, 2007 A method is proposed for the construction of descent directions for the minimization of energy functionals defined for plane curves. The method is potentially useful in a number of image analysis problems, such as image registration and shape warping ...
Niels Chr. Overgaard, Jan Erik Solem
doaj +1 more source
Application of numerical optimization to the design of wings with specified pressure distributions [PDF]
A practical procedure for the optimum design of transonic wings is demonstrated. The procedure uses an optimization program based on the method of feasible directions coupled with an aerodynamic analysis program which solves the three-dimensional ...
Haney, H. P., Johnson, R. R.
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
VaccinesDespite the use of direct-acting antiviral medications to treat hepatitis C virus (HCV), over a million people are newly infected each year, highlighting the need for a prophylactic vaccine.
Nicole E. Skinner
doaj +1 more source