Results 91 to 100 of about 145,410 (301)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Assessment of infiltrative margins in subcutaneous soft-tissue sarcomas using ultrasonography and gadolinium-enhanced fat-suppressed T1-weighted imaging

Surgery Open Science
Magnetic resonance imaging (MRI) aids in detecting infiltrative growth; however, preoperative determination of the extent of soft-tissue sarcoma (STS) infiltration remains challenging. Ultrasonography could also detect infiltration effectively.
Jun Iwatsu, Munenori Watanuki, Shinichirou Yoshida, Hirotaka Kurata, Shin Hitachi, Sota Oguro, Mika Watanabe, Toshimi Aizawa   +7 more
doaj   +1 more source

Sub‐slab anisotropy beneath the Sumatra and circum‐Pacific subduction zones from source‐side shear wave splitting observations

Geochemistry, Geophysics, Geosystems, 2014
Understanding the dynamics of subduction is critical to our overall understanding of plate tectonics and the solid Earth system. Observations of seismic anisotropy can yield constraints on deformation patterns in the mantle surrounding subducting slabs ...
Colton Lynner, Maureen D. Long
doaj   +1 more source

Design of cylindrical honeycomb cores – Geometric consideration –

Mechanical Engineering Journal, 2018
Lightweight and rigid honeycomb cores have a feature as deployable structures, i.e., their shapes can be changed as desired from the viewpoint of manufacturing processes.
Sachiko ISHIDA
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Practical implementation issues and future directions for active noise control [PDF]

, 1998
The basic physical principles underlying active noise control are discussed from a physical viewpoint with a view to understanding the issues which must be addressed in a practical implementation of the technology.
Hansen, C.
core   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Dynamic imaging of skeletal muscle contraction in three orthogonal directions. [PDF]

, 2010
Contains fulltext : 88821.pdf (Publisher’s version ) (Open Access)In this study, a multidimensional strain estimation method using biplane ultrasound is presented to assess local relative deformation (i.e., local strain) in three ...
Chris L. de Korte, Korte, de, C.L., Pillen, Sigrid, van Dijk, J.P, Stegeman, Dick F, Thijssen, Johan M., Huub Maas, Maas, Huub A. A. M., Maas, H.; id_orcid, Stegeman, Dick F., Stegeman, D.F., Korte, C.L. de, Thijssen, JM, Lopata, RGP Richard, Pillen, S., Dick F. Stegeman, Lopata, Richard G. P., Dijk, J.P. van, Johannes P. van Dijk, Dijk, JP van, Johan M. Thijssen, Richard G. P. Lopata, Nillesen, M.M., Thijssen, J.M., Nillesen, Maartje M., Lopata, R.G., van Dijk, Johannes P., Maas, H., Korte, C.L., Maas, Huub, Korte, CL de, Pillen, S, de Korte, Chris L., Dijk, van, J.P.; id_orcid, Lopata, R.G.P.; id_orcid, Lopata, R.G.P., Nillesen, M M, Sigrid Pillen, Maartje M. Nillesen, Dijk, van, J.P., Maas, H, Nillisen, M.M.   +41 more
core   +1 more source

Experimental results of a DOI-based directional radiation monitoring system

Nuclear Engineering and Technology
Monitoring technologies that provide source direction and radionuclide identification with omnidirectional real-time processing and multi-source detection are required for radiation accidents.
Yoon Soo Chung, Hee-Kyun Baek, Juwan Kang, Jiwon Ra, Yong Hyun Chung   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source