Results 91 to 100 of about 6,356,098 (354)

Learning From the Features We Ignore: A Critical Perspective on Feature Engineering and the Role of Feature Learning in Learning Analytics

IEEE Access
The integration of machine learning within educational environments has positioned learning analytics as a valuable approach for enhancing teaching and learning outcomes.
Dino Vlahek, Dijana Oreski, Marija Pokos Lukinec   +2 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Threat Vector–Hierarchical Attack Representation Model-Based Threat Modeling and Security Assessment for Satellite Networks

Applied Sciences
The rapid expansion of satellite networks has enabled the widespread deployment of satellite-based services across various sectors. However, these networks often prioritize cost-effectiveness over security considerations, leading to inherent ...
Junbeom Park, Taehoon Eom, Hyungeun Kim, Hyeonsu Park, Zizung Yoon, Jongsou Park   +5 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Autonomous Fault Detection in Self-Healing Systems using Restricted Boltzmann Machines [PDF]

, 2015
Autonomously detecting and recovering from faults is one approach for reducing the operational complexity and costs associated with managing computing environments.
Barker, Adam, Dobson, Simon, Schneider, Chris   +2 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Comparative Study of Feature Engineering Techniques for Predictive Data Analytics

Journal of Technology Informatics and Engineering
In the rapidly evolving era of big data, predictive analytics has become a crucial approach in supporting data-driven decision-making across various sectors such as finance, healthcare, and marketing.
Lukman Santoso, Priyadi
doaj   +1 more source

Game-Based Learning in Engineering Education [PDF]

, 2008
The new generation of undergraduates entering UK higher education have grown up with computer games of ever increasing sophistication. In this educational project a race game, Racing Academy, was developed to investigate how game technology and gaming ...
Darling, Jos, Drew, Ben, Gavin, Carl, Iacovides, Ioanna, Joiner, Richard   +4 more
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source