Results 141 to 150 of about 524,719 (351)

Feature-based detection of breast cancer using convolutional neural network and feature engineering

Scientific Reports
Breast cancer (BC) is a prominent cause of female mortality on a global scale. Recently, there has been growing interest in utilizing blood and tissue-based biomarkers to detect and diagnose BC, as this method offers a non-invasive approach.
Hiba Allah Essa, Ebrahim Ismaiel, Mhd Firas Al Hinnawi   +2 more
doaj   +1 more source

Special Issue “Feature Review Papers in Mechanical Engineering”

Applied Sciences
The study and advancement of crank-slide actuating mechanisms based on four-link structural groups are promising for the development of new designs of crank presses and other stamping and forging machines [...]
Paolo Renna, Michele Ambrico
doaj   +1 more source

Histogram Layers for Neural “Engineered” Features

IEEE Transactions on Artificial Intelligence
In the computer vision literature, many effective histogram-based features have been developed. These engineered features include local binary patterns and edge histogram descriptors among others and they have been shown to be informative features for a variety of computer vision tasks.
Joshua Peeples, Salim Al Kharsa, Luke Saleh, Alina Zare   +3 more
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

An Object-Oriented Formalism for Feature-Based Distributed Concurrent Engineering

, 2013
[[abstract]]The use of feature-based design and Concurrent Engineering promises substantial benefits but their successful implementation is hampered by the lack of a suitable formalism, particularly where, as is often the case, participants are ...
Liang, Wen-Yau; O'Grady, Peter
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Protein feature engineering framework for AMPylation site prediction

Scientific Reports
AMPylation is a biologically significant yet understudied post-translational modification where an adenosine monophosphate (AMP) group is added to Tyrosine and Threonine residues primarily.
Hardik Prabhu, Hrushikesh Bhosale, Aamod Sane, Renu Dhadwal, Vigneshwar Ramakrishnan, Jayaraman Valadi   +5 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source