Results 81 to 90 of about 946,604 (274)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

TIG Stainless Steel Molten Pool Contour Detection and Weld Width Prediction Based on Res-Seg

Metals, 2020
As the basic visual morphological characteristics of molten pool, contour extraction plays an important role in on-line monitoring of welding quality. The limitations of traditional edge detection algorithms make deep learning play a more important role ...
Yiming Wang, Jing Han, Jun Lu, Lianfa Bai, Zhuang Zhao   +4 more
doaj   +1 more source

Hierarchical Deep Learning Architecture For 10K Objects Classification

, 2015
Evolution of visual object recognition architectures based on Convolutional Neural Networks & Convolutional Deep Belief Networks paradigms has revolutionized artificial Vision Science.
Bedi, Amish Kumar, Chaitanya, Mynepalli Siva, Kalra, Sehaj Singh, Katole, Atul Laxman, Yellapragada, Krishna Prasad   +4 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Molten Pool Image Segmentation Based on Adaptive Multi-Scale Attention Mechanism

IEEE Access
This study presents an innovative segmentation algorithm that seamlessly integrates an adaptive multi-scale attention mechanism with the Lossab loss function to tackle challenges like overlapping molten pool contours and arc interference during image ...
Yuefeng Chen, Weihua Liu, Qing Yang, Huabin Chen, Qi Jiang   +4 more
doaj   +1 more source

Learning Representations from Persian Handwriting for Offline Signature Verification, a Deep Transfer Learning Approach

, 2019
Offline Signature Verification (OSV) is a challenging pattern recognition task, especially when it is expected to generalize well on the skilled forgeries that are not available during the training.
Araabi, Babak N., Etaati, Farhood, Masoudnia, Saeed, Mersa, Omid   +3 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Welding Defect Monitoring Based on Multi-Scale Feature Fusion of Molten Pool Videos

Sensors
Real-time quality monitoring through molten pool images is a critical focus in researching high-quality, intelligent automated welding. However, challenges such as the dynamic nature of the molten pool, changes in camera perspective, and variations in ...
Chenbo Shi, Lei Wang, Changsheng Zhu, Tengyue Han, Xiangyu Zhang, Delin Wang, Chun Zhang   +6 more
doaj   +1 more source

DC-SPP-YOLO: Dense Connection and Spatial Pyramid Pooling Based YOLO for Object Detection

, 2019
Although YOLOv2 approach is extremely fast on object detection; its backbone network has the low ability on feature extraction and fails to make full use of multi-scale local region features, which restricts the improvement of object detection accuracy ...
Huang, Zhanchao, Wang, Jianlin
core