Results 81 to 90 of about 202,798 (258)
A Magnetron Plasma Arc Fusion Identification Study Based on GPCC-CNN-SVM Multi-Source Signal Fusion
SensorsPlasma arc welding (PAW) is commonly employed for welding medium and thick plates due to its capability of single-side welding and double-side forming. Ensuring welding quality necessitates real-time precise identification of the melting state.
Yeming Zou +5 more
doaj +1 more source
Synapse clusters are preferentially formed by synapses with large recycling pool sizes.
PLoS ONE, 2010 Synapses are distributed heterogeneously in neural networks. The relationship between the spatial arrangement of synapses and an individual synapse's structural and functional features remains to be elucidated.
Oliver Welzel +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Melt-Pool Dynamics Quantification in LPBF via Move Contrast X-Ray Imaging
MetalsThe dynamic behavior within the melt pool governs the final quality of components fabricated by laser powder bed fusion (LPBF). To address key technical challenges—rapid keyhole evolution, low absorption contrast from metal vapor, and difficulties in ...
Zenghao Song +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Nature Communications, 2017 Accumulation of somatic mutations in lymphocytes is a feature of some cancers. Here the authors show that patients with recent onset of rheumatoid arthritis also accumulate mutations in their expanded CD8+ effector memory T cell pool independent of ...
P. Savola +18 more
doaj +1 more source
The Role of Node Features in Graph Pooling
Graph pooling is commonly applied in graph classification, yet its empirical gains over standard WL-1 expressive GNNs are often marginal or inconsistent. We study this gap by analysing the interaction between node features and graph topology and their effect on pooling objectives.
von Pichowski, Jan +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source