Results 51 to 60 of about 31,918 (237)

Venetoclax combined with cladribine, idarubicin, cytarabine (CLIA‐VEN) results in higher remission rates over conventional 7 + 3 chemotherapy without increased toxicity in newly diagnosed acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Summary Induction chemotherapy in fit de novo acute myeloid leukaemia (AML) patients has historically combined an anthracycline with standard‐dose cytarabine (‘7 + 3’) despite complete response (CR) rates of 50%–70%. In May 2023, our institution adopted the utilization of cladribine, cytarabine, idarubicin and venetoclax (CLIA‐VEN) for intensive ...
Benjamin J. Lee, Shawn P. Griffin, Jean Doh, Anthony Quach, Yujiao Sun, Piyatida Chumnumsiriwath, Stefan O. Ciurea, Jorge Ramos‐Perez, Polina Bellman, Deepa Jeyakumar, Piyanuch Kongtim, Kiran Naqvi   +11 more
wiley   +1 more source

Uso de factores de crescimento de granulócitos: recomendações da Sociedade Portuguesa de Hematologia.

Acta Médica Portuguesa, 2008
The administration of cytotoxic chemotherapy may be complicated by the emergence of neutropenia and febrile neutropenia, frequently determining hospital admission and intravenous treatment with broad spectrum antibiotics.
João Forjaz de Lacerda, Fernando Leal da Costa, Ana Marques Pereira, Fernando Príncipe, Adriana Teixeira, António Parreira   +5 more
doaj   +1 more source

Phase II study of the triple combination of rabbit ATG, ciclosporin and eltrombopag in patients with transfusion‐dependent aplastic anaemia: West Japan Hematology Study Group (W‐JHS) AA02 trial

British Journal of Haematology, EarlyView.
Summary The efficacy of a triple combination of rabbit anti‐human thymocyte immunoglobulin (rATG), ciclosporin and eltrombopag (EPAG) was prospectively evaluated in patients with severe or transfusion‐dependent non‐severe aplastic anaemia (SAA) across 29 institutions in Japan. Sixty patients were enrolled, of whom 48 had SAA. The primary end‐point, the
Fumi Nakamura, Ken Ishiyama, Ritsuro Suzuki, Hiroyuki Maruyama, Yasushi Onishi, Kensuke Usuki, Hideo Koh, Katsuto Takenaka, Ryunosuke Saiki, Seishi Ogawa, Kana Matsumoto, Takuto Takahashi, Kazuyoshi Hosomichi, Yoshitaka Zaimoku, Kenichi Yoshimura, Itaru Matsumura, Koichi Akashi, Shinji Nakao   +17 more
wiley   +1 more source

Neutropenia febril

Revista Española de Casos Clínicos en Medicina Interna, 2020
La quimioterapia deprime la mielopoyesis y afecta a la integridad de las mucosas gastrointestinales aumentando el riesgo de infecciones sistémicas por translocación de bacterias y hongos. La neutropenia febril es una complicación grave cuya tasa de mortalidad es de hasta el 11%.
María Mar Cutillas-Pérez, Cristina Macía-Rodríguez, Lucía Santomé-Couto, Javier de la Fuente-Aguado   +3 more
openaire   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

A de-escalation protocol for febrile neutropenia cases and its impact on carbapenem resistance: A retrospective, quasi-experimental single-center study

Journal of Infection and Public Health, 2016
Our objective was to evaluate the impact of using an imipenem de-escalation protocol for empiric febrile neutropenia on the development of carbapenem resistance.A pre-post intervention design was used.
Abeer Alshukairi, Haleema Alserehi, Aiman El-Saed, Mouhammed Kelta, Jalil U. Rehman, Farrukh A. Khan, Hanadi Alsalmi, Majda Alattas, Muhammad Aslam   +8 more
doaj   +1 more source

Malnutrition is a predisposing factor for developing recurrent fever following febrile neutropenia in children with acute lymphoblastic leukemia

Pediatric Hematology Oncology Journal, 2020
Introduction: The factors that predict recurrence of fever following defervescence (DS) during febrile neutropenia (FN) episode have not been studied. The objective was to estimate the incidence and risk factors for recurrent fever (RF) in children with ...
Jaikumar Govindaswamy Ramamoorthy, Venkatraman Radhakrishnan, Prasanth Ganesan, Manikandan Dhanushkodi, T.S. Ganesan, T.G. Sagar   +5 more
doaj   +1 more source

Effectiveness and Safety of Radium‐223 for Bone‐Metastatic Castration‐Resistant Prostate Cancer: The KYUCOG‐1901 Study

Cancer Science, EarlyView.
The KYUCOG‐1901 prospective multicenter study evaluated radium‐223 in 93 Japanese patients with bone‐metastatic castration‐resistant prostate cancer. Ra‐223 was well tolerated, produced meaningful declines in ALP, and yielded a median overall survival of 23.0 months. Early initiation in patients with lower disease burden and integration with subsequent
Masaki Shiota, Shuichi Tatarano, Tomomi Kamba, Toshiyuki Kamoto, Tsukasa Igawa, Naoya Masumori, Hirotsugu Uemura, Kensuke Mitsunari, Takayuki Sumiyoshi, Hiroji Uemura, Katsuyoshi Higashijima, Shoji Tokunaga, Masatoshi Eto   +12 more
wiley   +1 more source

Chemotherapy Induced Neutropenia, Febrile-Neutropenia and Determinants Among Solid Cancer Patients Attending Oncology Unit of a Tertiary Care Teaching Hospital in Ethiopia

Cancer Management and Research, 2023
Mekonnen Dessalegn,1,2 Mengistu Fantahun,2 Abdu Adem Yesufe,2 Mintewab Hussein,1 Aster Tsegaye1 1Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 2St Paul’s Hospital Millennium Medical ...
Dessalegn M, Fantahun M, Yesufe AA, Hussein M, Tsegaye A   +4 more
doaj  

Perioperative Nivolumab in Resectable Non‐Small Cell Lung Cancer: A Subanalysis of Japanese Patients From CheckMate 77T

Cancer Science, EarlyView.
ABSTRACT In the randomized phase III CheckMate 77T study, perioperative nivolumab showed statistically significant and clinically meaningful improvement in event‐free survival (EFS) vs. placebo in patients with resectable, non‐metastatic non‐small cell lung cancer (NSCLC).
Fumihiro Tanaka, Yasutaka Watanabe, Shunichi Sugawara, Jiro Okami, Satoshi Muto, Morihito Okada, Yoshitsugu Horio, Masahiro Tsuboi, Yuki Sato, Kazuya Takamochi, Hidehito Horinouchi, Yuichi Tambo, Masahiro Seike, Kyoichi Okishio, Cinthya Coronado Erdmann, Padma Sathyanarayana, Stephanie Meadows‐Shropshire, Hiroyuki Ito   +17 more
wiley   +1 more source