Results 91 to 100 of about 6,049 (169)

Xanthine oxidoreductase inhibition ameliorates high glucose-induced glomerular endothelial injury by activating AMPK through the purine salvage pathway

Scientific Reports
Xanthine oxidoreductase (XOR) contributes to reactive oxygen species production. We investigated the cytoprotective mechanisms of XOR inhibition against high glucose (HG)-induced glomerular endothelial injury, which involves activation of the AMP ...
Keum-Jin Yang, Hwajin Park, Yoon-Kyung Chang, Cheol Whee Park, Suk Young Kim, Yu Ah Hong   +5 more
doaj   +1 more source

Comparative efficacy and safety of febuxostat and allopurinol in chronic kidney disease stage 3–5 patients with asymptomatic hyperuricemia: a network meta-analysis

Renal Failure
Objective This study evaluates and compares the effectiveness and safety of febuxostat and allopurinol in chronic kidney disease (CKD) stages 3–5 patients with asymptomatic hyperuricemia using a network meta-analysis.Methods A systematic review and ...
Jiaojiao Chen, Yanyun Zhang, Yinglin Wang, Lu Chen   +3 more
doaj   +1 more source

Febuxostat efficiently reduces the progression of chronic kidney disease in asymptomatic hyperuricemia: an interventional study

The Egyptian Journal of Internal Medicine
Background Therapeutic approaches for addressing asymptomatic chronic kidney disease (CKD) with renal impairment requires careful consideration, as there is a lack of substantial evidence endorsing specific medications.
Showkat Azad, Pradip Kumar Dutta, Md Nurul Huda, Mohammad Abdul Kader, Biplob Kumar Barua, Mohammad Shawkat Ali, Maria Mehjabin Akhi, Mishu Rahman, Jannatul Efte Ekra, Md. Sujan Islam, Sadia Afrin, Mohammed Mehadi Hassan Chowdhury, Subodh Kumar Sarkar, Ashekul Islam   +13 more
doaj   +1 more source

Efectividad del febuxostat en pacientes hiperuricémicos. Revisión sistemática [PDF]

La hiperuricemia es una patología crónica curable causada por el depósito de cristales de urato monosódico en articulaciones y tejidos periarticulares, como consecuencia del incremento de ácido úrico sérico.
Calle Crespo, Víctor Manuel
core   +1 more source

Cardiovascular safety of febuxostat versus allopurinol among the Asian patients with or without gout: A systematic review and meta‐analysis

Clinical and Translational Science
The cardiovascular (CV) safety of febuxostat compared to allopurinol for the treatment of hyperuricemia among Asian patients is uncertain. In this study, we conducted a systematic review and meta‐analysis to compare the CV safety profiles of febuxostat ...
Jian‐hao Deng, Peng‐hui Lai, Li‐shan Xie, Shu‐sheng Qiu, De‐sheng Qiu, Jia‐xing Zhang   +5 more
doaj   +1 more source

Comparative assessment of the effects of dotinurad and febuxostat on the renal function in chronic kidney disease patients with hyperuricemia

Scientific Reports
Although hyperuricemia is associated with chronic kidney disease (CKD), the impact of uric acid (UA)-lowering drugs on CKD has been controversial.
Tomoaki Takata, Sosuke Taniguchi, Yukari Mae, Kana Kageyama, Yudai Fujino, Takuji Iyama, Katsuya Hikita, Takaaki Sugihara, Hajime Isomoto   +8 more
doaj   +1 more source

Febuxostat inhibits airway inflammation and lung fibrosis in a mouse model of lipopolysaccharide-induced lung injury [PDF]

Reduced adenosine triphosphate （ATP） levels due to mitochondrial dysfunction induces lung injury in acute respiratory distress syndrome （ARDS）. Considering that febuxostat improves mitochondrial dysfunction and reduces ATP consumption, its effects were ...
IKEDA, Hitoshi, SAGARA, Hironori, WATANABE, Yoshio, EDA, Yoko, GOTO, Yuiko, KAMATANI, Naoyuki, TANAKA, Akihiko, KUSUMOTO, Sojiro, OHTA, Shin, KITSU, Chihiro   +9 more
core  

Pembentukan dan Karakterisasi Multikomponen Kristal Febuxostat – Asam Siringat dengan Metode Penggilingan Basah [PDF]

Febuxostat merupakan obat golongan inhibitor xantin oksidase selektif non-purin dengan efek farmakologi mengurangi produksi asam urat. Berdasarkan Biopharmaceutical Classification System (BCS), febuxostat termasuk dalam BCS kelas II yang mempunyai ...
Fitri, Gita Sri
core  

Predictors of reaching a serum uric acid goal in patients with gout and treated with febuxostat

ClinicoEconomics and Outcomes Research, 2017
Richard Sheer,1 Kyle D Null,2 Keith A Szymanski,2 Lavanya Sudharshan,1 Jennifer Banovic,2 Margaret K Pasquale1 1Comprehensive Health Insights, Inc., Louisville, KY, 2Takeda Pharmaceuticals U.S.A., Inc., Deerfield, IL, USA Purpose: Clinical guidelines ...
Sheer R, Null KD, Szymanski KA, Sudharshan L, Banovic J, Pasquale MK   +5 more
doaj  

Yinlian Tongfeng Granules: A Promising Clinical Treatment Option for Gouty Arthritis. [PDF]

Int J Rheum Dis
Xie M, Ding X, Zhai X, Li M, Zhou M.
europepmc   +1 more source