Results 291 to 300 of about 349,940 (358)

A Fast Path from Innovation to Safe and Effective Medicines

Clinical Pharmacology &Therapeutics, EarlyView.
Consistent progress in medicines development has allowed both for de novo treatment options and for the refinement of existing products that improve effectiveness or reduce harm. Nonetheless, unmet medical needs persist, particularly in rare diseases, pediatrics and underserved populations.
Peter Arlett, Falk Ehmann, Ralf Herold, Evdokia Korakianiti, Pierpaolo Moscariello, Liese Barbier, Iordanis Gravanis, Frank Pétavy, Emmanuel Cormier, Andrew Thomson, Spiros Vamvakas, Steffen Thirstrup   +11 more
wiley   +1 more source

Maternal administration of octanoate, a medium-chain fatty acid, improves feed efficiency of Japanese black calves through influencing gut bacteriome structure. [PDF]

Sci Rep
Yamano H, Horike H, Taguchi Y, Inabu Y, Miyamoto H, Kurotani A, Suzuki N, Moriya S, Nakaguma T, Ishii C, Matsuura M, Tsuji N, Etoh T, Shiotsuka Y, Fujino R, Wada S, Kikuchi J, Ohno H, Takahashi H.   +18 more
europepmc   +1 more source

Fifty years of research on the Joulters ooid sandbody—Impact on carbonate sedimentology and diagenesis and lessons learned from an invaluable analogue

The Depositional Record, EarlyView.
The Joulters ooid sandbody of northern Great Bahama Bank is a vast expanse of muddy ooid sands partly rimmed by clean ooid sands and formed into a relatively thick layer of significant extent. Knowledge of the development of depositional and diagenetic patterns in the Joulters example has forwarded our general understanding of carbonate sedimentology ...
Paul (Mitch) Harris
wiley   +1 more source

Environmental Application of a Bacteriophage Cocktail Reduces Antibiotic-Resistant <i>Escherichia coli</i> in Poultry Litter Without Disrupting Gut Microbiota. [PDF]

Animals (Basel)
Kuźmińska-Bajor M, Kuczkowski M, Konkol D, Korczyński M, Rakicka-Pustułka M, Kozioł S, Tomaszewska-Hetman L, Rywińska A.   +7 more
europepmc   +1 more source

Late Pleistocene to Holocene sedimentation in the Great Blue Hole (Lighthouse Reef, Belize): Results from a 30 m long core

The Depositional Record, EarlyView.
A 30 m long sedimentary succession at the bottom of the Belize Blue Hole represents terrestrial cenote (12.5–7.2 ka BP), restricted marine swamp (7.2–5.7 ka BP) and fully marine lagoonal phases (5.7–0 ka BP) on Lighthouse Reef carbonate platform. Post‐glacial and Holocene sea‐level rise largely controlled the sedimentological, faunal and floral changes
Eberhard Gischler, Dominik Schmitt, Annika Wiegand, Hermann Behling, Lyudmila Shumilovskikh, Martin Melles, Volker Wennrich, Elija Nolte, Jozef Grego, Flavio S. Anselmetti, Hendrik Vogel, Daniel Birgel, Jörn Peckmann   +12 more
wiley   +1 more source

Effects of yeast beta-1,3/1,6-glucans on nutrient digestibility, intestinal functionality, and immune and antioxidant variables in growing dogs submitted to spay or neutering surgery. [PDF]

PLoS One
de Souza RBMDS, Fernandes EL, Araújo Santos LN, da Silva Lima L, Silva HL, Putarov TC, de Oliveira SG, Félix AP.   +7 more
europepmc   +1 more source

The Cenomanian–Turonian boundary interval in the Western Canada Foreland Basin: Stratigraphy, geochemistry, geochronology and sea‐level changes recorded in expanded and condensed clastic successions

The Depositional Record, EarlyView.
Shallow‐marine mudstone of the Cretaceous Kaskapau Formation in the British Columbia foredeep preserves a 185 m thick record of OAE2. The organic carbon‐isotope and osmium‐isotope excursions can be correlated in detail with other Cenomanian–Turonian boundary sections around the world.
A. Guy Plint, Darren R. Gröcke, David Selby, Ireneusz Walaszczyk, Sandra L. Kamo, Ian Jarvis, João Trabucho‐Alexandre, Jessica Flynn, Frederick J. Longstaffe, Kienan P. Marion, Bogdan L. Varban, Alice D. C. Du Vivier, David Uličný   +12 more
wiley   +1 more source

Effects of Dietary Resveratrol Supplementation on Fermentation Characteristics, Microbial Diversity, and Community Composition of Feces in Hu Sheep. [PDF]

Animals (Basel)
Luo D, Li L, Cui C, Ouyang K, Qu M, Qiu Q.   +5 more
europepmc   +1 more source

Ichnological discrimination of hemipelagic‐dominated slope versus basin‐floor mudstones: Insights from early Viséan successions of a distally steepened ramp, northern Iran

The Depositional Record, EarlyView.
This study integrates sedimentological and ichnological data to reveal the depositional processes and environmental conditions of deep‐water muddy gravity flows in the Mobarak Formation. It highlights distinct ichnocoenoses and bioturbation patterns, offering insights into basin‐floor versus slope mudstones and their implications for hydrocarbon ...
Aram Bayet‐Goll, Mahmoud Sharafi, Mehdi Daraei   +2 more
wiley   +1 more source

Zoonotic and Environmental Sources of Infant Enteric Pathogen Infections Identified with Longitudinal Sampling. [PDF]

Environ Sci Technol
Paulos AP, Mboya J, Lowe J, Kim DD, Wharton HC, Thuita F, Flax VL, Njenga SM, Harris AR, Pickering AJ.   +9 more
europepmc   +1 more source