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Biological sulphide oxidation in a fed‐batch reactor
Biotechnology and Bioengineering, 1995AbstractThis study shows that, in a sulphide‐oxidizing bioreactor with a mixed culture of Thiobacilli, the formation of sulphur and sulphate as end‐products from the oxidation of sulphide can be controiledinstantaneously and reversibiy by the amount of oxygen supplied. It was found that at sulphide loading rates of up to 2.33 mmol7/L · h, both products
Janssen, A.J.H. +5 more
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2013
Fed-batch reactor is based on feeding of a growth limiting nutrient substrate to a culture. Cell growth and fermentation can be controlled by the feeding strategy. The fed-batch strategy is typically used to reach a high cell density in the bioreactor or mimic a continuous culture. Mostly the feed solution is highly concentrated.
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Fed-batch reactor is based on feeding of a growth limiting nutrient substrate to a culture. Cell growth and fermentation can be controlled by the feeding strategy. The fed-batch strategy is typically used to reach a high cell density in the bioreactor or mimic a continuous culture. Mostly the feed solution is highly concentrated.
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Fed-batch operation of stirred reactors
Chemical Engineering Science, 1987Abstract Numerical algorithm for the computation of the dependence of periodic solutions on parameters in fed-batch or periodically operating reactors is described. Results for the simulation of a simple model of anaerobic digester and of a first order exothermic reaction are then discussed and various types of m -periodic solutions are presented ...
Z. Kubičkova, M. Kubiček, M. Marek
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Industrial Fed-Batch Fermentation Monitoring
IFAC Proceedings Volumes, 1997Abstract A multivariate statistical model is developed and used for fault diagnosis of an industrial fed-batch fermentation process. Process faults may be detected on-line using existing measurements. In the applied approach the modelling is entirely data driven. Several data sets (25) are used to develop a model for cultivation behaviour. This model
Maria Yolanda Andersen +2 more
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2020
The cells used in cell culture processes are all derived from animals. Their genetic and epigenetic control circuits and their physiology have evolved to carry out the physiological functions of the tissue from which they were derived, not to sustain themselves and proliferate in in vitro culture.
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The cells used in cell culture processes are all derived from animals. Their genetic and epigenetic control circuits and their physiology have evolved to carry out the physiological functions of the tissue from which they were derived, not to sustain themselves and proliferate in in vitro culture.
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Production of pullulan by a fed-batch fermentation
Biotechnology Letters, 1987In pullulan production from sucrose byAureobasidium pullulans, a sugar concentration higher than 5% (w/v) inhibited cell growth and the production of exopolysaccharide. By a fed-batch fermentation, the inhibitory effects of the high sugar concentration were overcome and 58.0 g/1 of exopolysaccharide were obtained from 10% sucrose.
Yong Chul Shin +4 more
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The Snowball Effect in Fed-Batch Bioreactions
Biotechnology Progress, 2003The bioreactor will play an important role in future biological manufacturing. For economic profit, important profiles of the feed rate in fed-batch cultures have been discussed. Unfortunately, the optimal feed rate is less robust. In these studies there exists the snowball effect in a substrate-inhibited bioprocess, in which substrate is accumulated ...
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An analysis of extended and exponentially‐fed‐batch cultures
Biotechnology and Bioengineering, 1977AbstractUnder certain conditions it is shown that an extended culture is equivalent to an exponentially‐fed‐batch culture, that an exponentially‐fed‐batch culture (and an extended culture) can be maintained at a steady state and that an exponentially‐fed‐batch culture may be mimicked by a continuous‐flow culture with a constant dilution rate ...
Bill J. Chen +2 more
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Refolding of enzymes in a fed-batch operation
Process Biochemistry, 1999Abstract Denatured and fully reduced lysozyme and ribonuclease A were refolded in batch and also in fed-batch operation. In fed-batch refolding of lysozyme, denatured lysozyme was gradually added into refolding buffers containing urea in the concentration range from 1.0 to 2.0 mol/l.
Takashi Yamaguchi +5 more
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Fed-batch fermentation for ergosterol production
Process Biochemistry, 2003Abstract The relationship between the fermentation parameters pH, DO and the concentrations of glucose, biomass and the ergosterol content of Saccharomyces cerevisiae in different fed-batch methods are discussed. Different fed-batch methods including constant feed rate fed-batch, constant glucose concentration fed-batch, exponential fed-batch, DO ...
Tianwei Tan, Hua Gao
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