Results 261 to 270 of about 101,209 (306)

Fed-Batch Cultivation

2013
Fed-batch reactor is based on feeding of a growth limiting nutrient substrate to a culture. Cell growth and fermentation can be controlled by the feeding strategy. The fed-batch strategy is typically used to reach a high cell density in the bioreactor or mimic a continuous culture. Mostly the feed solution is highly concentrated.
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Fed-Batch Culture Processes

2020
The cells used in cell culture processes are all derived from animals. Their genetic and epigenetic control circuits and their physiology have evolved to carry out the physiological functions of the tissue from which they were derived, not to sustain themselves and proliferate in in vitro culture.
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Adaptive Optimal Control of Fed-Batch Alcoholic Fermentation

Applied Biochemistry and Biotechnology, 1998
An adaptive control scheme is developed for the optimization of a fed-batch ethanol production process. The fermentation process is modeled by an hybrid neural model combining mass balance equations and neural networks, used to represent the kinetic rates.
T L, Alves, A C, Costa, A W, Henriques, E L, Lima   +3 more
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Fed-batch operation of stirred reactors

Chemical Engineering Science, 1987
Abstract Numerical algorithm for the computation of the dependence of periodic solutions on parameters in fed-batch or periodically operating reactors is described. Results for the simulation of a simple model of anaerobic digester and of a first order exothermic reaction are then discussed and various types of m -periodic solutions are presented ...
Z. Kubičkova, M. Kubiček, M. Marek
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Extended cyclic fed-batch tylosin fermentations

Biotechnology Letters, 1987
Biosynthesis of the macrolide antibiotic tylosin was studied in fed-batch fermentations. When glucose and sodium glutamate were fed to the fermentation in a cyclic square wave fashion with a period of 24 hours, it was possible to maintain high initial rates of tylosin biosynthesis for up to 240 hours before the synthetic rate decreased. By adding basic
P. P. Gray, K. Vu-Trong
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Fed-batch versus batch fermentation

Bioprocess Engineering, 1994
This article concerns the comparison between batch and fed-batch fermentation based on productivity and including the analysis of the implications on product manufacturing cost.
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Robust operation of fed batch fermenters

Bioprocess Engineering, 1998
Optimisation of fed batch fermenters can substantially increase the profitability of these processes. Optimal control of a fed batch fermenter is usually based on a nominal process model. Parameter uncertainties are not taken into account. Simulation studies show that results obtained with fixed nominal model parameters can be quite sensitive to the ...
C. Kuhlmann, I. D. L. Bogle, Z. S. Chalabi   +2 more
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Fed-batch fermentation for ergosterol production

Process Biochemistry, 2003
Abstract The relationship between the fermentation parameters pH, DO and the concentrations of glucose, biomass and the ergosterol content of Saccharomyces cerevisiae in different fed-batch methods are discussed. Different fed-batch methods including constant feed rate fed-batch, constant glucose concentration fed-batch, exponential fed-batch, DO ...
Hua Gao, Tianwei Tan
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The Snowball Effect in Fed-Batch Bioreactions

Biotechnology Progress, 2003
The bioreactor will play an important role in future biological manufacturing. For economic profit, important profiles of the feed rate in fed-batch cultures have been discussed. Unfortunately, the optimal feed rate is less robust. In these studies there exists the snowball effect in a substrate-inhibited bioprocess, in which substrate is accumulated ...
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Fed-batch and continuous culture

1990
Abstract A variety of techniques has been developed for the submerged culture of microorganisms. Batch and fed-batch culture have been part of the art of fermentation since antiquity and are still used today for most industrial fermentations.
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