Results 71 to 80 of about 111,815 (303)

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

Enhancing Biomass Production and Biodesulfurization Efficiency of Rhodococcus qingshengii IGTS8: Evaluation of Batch, Repeated Batch and Fed-Batch Cultivation Techniques

Applied Sciences
The batch, repeated batch and fed-batch cultivation strategies, in stirred tank bioreactors, were evaluated to maximize biomass production and the cells’ desulfurization activity (CDA) of Rhodococcus qingshengii IGTS8.
Konstantinos Dimos, Styliani Kalantzi, George Prasoulas, Panagiotis D. Gklekas, Olga Martzoukou, Dimitris G. Hatzinikolaou, Dimitris Kekos, Diomi Mamma   +7 more
doaj   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Strategies for improved rhamnolipid production by Pseudomonas aeruginosa PA1 [PDF]

PeerJ, 2016
Rhamnolipids are biosurfactants with potential for diversified industrial and environmental uses. The present study evaluated three strategies for increasing the production of rhamnolipid-type biosurfactants produced by Pseudomonas aeruginosa strain PA1.
Alexandre Soares dos Santos, Nei Pereira Jr, Denise M.G. Freire   +2 more
doaj   +2 more sources

A simple method to determine evaporation and compensate for liquid losses in small-scale cell culture systems [PDF]

, 2018
Objectives: Establish a method to indirectly measure evaporation in microwell-based cell culture systems and show that the proposed method allows compensating for liquid losses in fed-batch processes.
Baganz, F, Martinez, CB, Wiegmann, V
core   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Novel approach of high cell density recombinant bioprocess development: Optimisation and scale-up from microlitre to pilot scales while maintaining the fed-batch cultivation mode of E. coli cultures

Microbial Cell Factories, 2010
Background Bioprocess development of recombinant proteins is time consuming and laborious as many factors influence the accumulation of the product in the soluble and active form.
Rimšeliene Renata, Kraft Mario, Horn Uwe, Šiurkus Juozas, Panula-Perälä Johanna, Neubauer Peter   +5 more
doaj   +1 more source

Development of Fermentation Technique for High Cell Density Cultivation of Baker's Yeast (Saccharomyces Cerevisae) [PDF]

, 2005
The yeast, Saccharomyces cerevisae, isolated from fermented food was used in this study. Batch fermentation studies of S. cerevisae in a 2 L stirred tank fermenter were undertaken to generate kinetic growth data for the design of continuous and fed ...
Ahmad Ariff,
core  

The physiology of erythromycin biosynthesis in cyclic fed batch culture [PDF]

Microbiology, 1995
Antibiotic production in Saccharopolyspora erythraea was significantly enhanced in cyclic fed batch culture (c.f.b.c) compared to batch culture, whereas chemostat culture resulted in reduced production. C.f.b.c. allowed the specific growth rate to be varied, with time, according to an asymptotically decreasing trajectory without the necessity for ...
H C, Lynch, M E, Bushell
openaire   +2 more sources